Seborrheic Keratoses: The Rodney Dangerfield of Skin lesions, and Why They Should Get Our Respect.

Jack L Arbiser, Michael Y Bonner

Open access · greenAbstract readComment

In one paragraph

Article in The Journal of investigative dermatology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

1.0field-weighted citation impact, top 23% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

Genetic alterations in seborrheic keratoses.Oncotarget · 2017
Article

4 · The record

Corrections and comments

Comment on
Sustained Akt Activity Is Required to Maintain Cell Viability in Seborrheic Keratosis, a Benign Epithelial Tumor.2016

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Jack L ArbiserDepartment of Dermatology, Emory School of Medicine, and Winship Cancer Institute, Atlanta, Georgia, USA; Dermatology Veterans Affairs Medical Center, Decatur, Georgia, USA. Electronic address: jarbise@emory.edu.

Michael Y BonnerDepartment of Dermatology, Emory School of Medicine, and Winship Cancer Institute, Atlanta, Georgia, USA.

Emory and Henry College · USEmory University · US

Funding

Cutaneous Hemangiomas and Signal TransductionR01AR047901 · NIAMS · EMORY UNIVERSITY · PI ARBISER, JACK L · 2001 to 2018

$4.3M

UV light and the cutaneous neurosensory systemP30AR042687 · NIAMS · EMORY UNIVERSITY · PI CAUGHMAN, STEWART W · 1994 to 2003

$2.5M

NIAMS NIH HHS P30 AR042687NIAMS NIH HHS P30 AR42687NIAMS NIH HHS R01 AR047901NIAMS NIH HHS R01 AR47901

6 · The paper itself

Abstract

Neel et al. have demonstrated that seborrheic keratosis, the most common of all skin tumors, is dependent on acutely transforming retrovirus AKT8 in rodent T-cell lymphoma signaling. The authors found that these lesions are hypersensitive to Akt inhibitors which bind to the ATP binding site of Akt. Cutaneous squamous cell carcinoma is resistant to Akt inhibitors. The implications of this study are not limited to seborrheic keratosis. The presence of wild type p53 (seborrheic keratosis) or mutant p53 (cutaneous squamous cell carcinoma) appears to dictate whether a lesion is sensitive to Akt inhibition or not.

Indexed as

Cell SurvivalCell Transformation, NeoplasticHumansKeratosis, SeborrheicProto-Oncogene Proteins c-aktReceptor, Fibroblast Growth Factor, Type 3Proto-Oncogene Proteins c-aktReceptor, Fibroblast Growth Factor, Type 3

Identifiers

PMID26902127

DOI10.1016/j.jid.2015.12.019

PMCPMC5925755

OpenAlexW2274505925

What OpenQuestion holds

Textmetadata

LicenceTDM

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.