ArticlePain2016
Chronic pain in adolescence and internalizing mental health disorders: a nationally representative study.
Article in Pain, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
101 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Pooled it
- Physical activity and education about physical activity for chronic musculoskeletal pain in children and adolescents.The Cochrane database of systematic reviews · 2023Pooled it
- Pooled it
- Psychological therapies (remotely delivered) for the management of chronic and recurrent pain in children and adolescents.The Cochrane database of systematic reviews · 2019Pooled it
- The effect of a smartphone-based pain management application on pain intensity and quality of life in adolescents with chronic pain.Scientific reports · 2021Trial
- Moderators of Internet-Delivered Cognitive-Behavioral Therapy for Adolescents With Chronic Pain: Who Benefits From Treatment at Long-Term Follow-Up?The journal of painTrial
- Alcohol use in adolescent chronic pain: Prevalence rates, perceptions of risk, and predictors of use.Drug and alcohol dependence reports · 2026Article
- Chronic Physical Pain in Children With and Without Autism Spectrum Disorder in the United States: Findings from the 2016 - 2021 National Survey of Children's Health.Journal of autism and developmental disorders · 2026Article
- Article
- Lower resting-state functional connectivity between frontoparietal and sensory networks is associated with recent pain intensity in a community sample of youth.Neuroimage. Reports · 2026Article
- Fatigue and pain in children with multiple osteochondromas: a cross-sectional study.Orphanet journal of rare diseases · 2026Article
- Assessing relationships between cognition, sleep, and mental health in pediatric patients with chronic pain.The journal of pain · 2026Observational
- PURSUIT Protocol: Development of a Novel Approach to Managing Youth Physical and Mental Health in Schools.Children (Basel, Switzerland) · 2026Article
- Article
- Decoding pain and mental health patterns in youth with chronic pain during COVID-19.Frontiers in pain research (Lausanne, Switzerland) · 2026Article
- Persistent musculoskeletal pain and its association with future mental distress in adolescents: The Fit Futures study.BMC public health · 2025Article
- The emergence of sex differences in primary pain during adolescence: a conceptual developmentally-oriented biopsychosocial model and opportunities for further investigation.BMC pediatrics · 2025Review
- Understanding the Comorbidities Among Psychiatric Disorders, Chronic Low Back Pain, and Spinal Degenerative Disease Using Observational and Genetically Informed Analyses.Biological psychiatry global open science · 2025Article
- Abnormal structural gray matter and structural covariance networks associated with biopsychosocial characteristics in children with multisite pain.The journal of headache and pain · 2025Article
- Pain neuroscience education improves knowledge and satisfaction in adolescents with and without intellectual disabilities: a cross-sectional study.Acta neuropsychiatrica · 2025Article
41 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Chronic pain in childhood and adolescence has been shown to heighten the risk for depressive and anxiety disorders in specific samples in adulthood; however, little is known about the association between a wider variety of chronic pains and internalizing mental health disorders. Using nationally representative data, the objectives of this study were to establish prevalence rates of internalizing mental health disorders (anxiety and depressive disorders) among cohorts with or without adolescent chronic pain, and to examine whether chronic pain in adolescence is associated with lifetime history of internalizing mental health disorders reported in adulthood. Data from the National Longitudinal Study of Adolescent to Adult Health (Add Health) was used (N = 14,790). Individuals who had chronic pain in adolescence subsequently reported higher rates of lifetime anxiety disorders (21.1% vs 12.4%) and depressive disorders (24.5% vs 14.1%) in adulthood as compared with individuals without a history of adolescent chronic pain. Multivariate logistic regression confirmed that chronic pain in adolescence was associated with an increased likelihood of lifetime history of anxiety disorders (odds ratio: 1.33; 95% confidence interval: 1.09-1.63, P = 0.005) and depressive disorders (odds ratio: 1.38; confidence interval: 1.16-1.64, P < 0.001) reported in adulthood. Future research is needed to examine neurobiological and psychological mechanisms underlying these comorbidities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.