ReviewSmall (Weinheim an der Bergstrasse, Germany)2016
Fluorescent Polymer Nanoparticles Based on Dyes: Seeking Brighter Tools for Bioimaging.
Review in Small (Weinheim an der Bergstrasse, Germany), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 120 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
120 citing papers in PubMed.
- Click'n ROPISA: One-Pot Synthesis of Ultrabright Fluorescent Nanoparticles Made of Polypeptides.Angewandte Chemie (International ed. in English) · 2026Article
- Fluorescent Labeling Strategies for Tracking Micro- and Nanoplastics in Biological Systems.Materials (Basel, Switzerland) · 2026Review
- Donor-Acceptor Organic Fluorophores Encapsulated in Polystyrene Nanoparticles as High-Brightness Reporters for Fluorescent Lateral Flow Immunoassay of C-Reactive Protein.Journal of fluorescence · 2026Article
- Comprehensive Insight into the Emerging World of Carbon Dots for Applications in Energy and Metal Ion Sensing.Precision chemistry · 2026Review
- Fluorescence Analysis of Local Microenvironments in Polymer Films Using Solvatochromic Dyes.Sensors (Basel, Switzerland) · 2026Article
- Intravital microscopy for nanomedicine: investigating nanoparticle-tissue interactions in the native state.RSC advances · 2026Review
- A printable, unimolecular, core-shell polymer bottlebrush-based signal transducer using solvatochromatic reporting.Chemical science · 2026Article
- Fluorescent nanoplastics: What steps are needed towards a representative toolkit?Microplastics and nanoplastics · 2026Review
- Triazole-Based Functionalized Olygo(Arylene Ethynylene)s-Synthesis and Properties.Molecules (Basel, Switzerland) · 2025Article
- Light-Harvesting Nanomaterials Based on Dyes for Energy Transfer and Amplified Biosensing.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- Toward Organic Mimics of Metallic Nanoparticles: Tuning and Enhancing Fluorescence in Binary Dye-Based Nanoparticles.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Inter-Nanoparticle FRET for Biosensing: Photophysics Versus Size.Angewandte Chemie (International ed. in English) · 2025Review
- Article
- Thermoresponsive and Fluorescent Polymers: From Nanothermometers to Smart Drug Delivery Systems for Theranostics Against Cancer.Pharmaceutics · 2025Review
- Design Principles of Nanosensors for Multiplex Detection of Contaminants in Food.Small (Weinheim an der Bergstrasse, Germany) · 2025Review
- Labelizer: systematic selection of protein residues for covalent fluorophore labeling.Nature communications · 2025Article
- Influence of Measurement Geometry and Blank on Absolute Measurements of Photoluminescence Quantum Yields of Scattering Luminescent Films.Analytical chemistry · 2025Article
- Stepwise Modulation of Bridged Single-Benzene-Based Fluorophores for Materials Science.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Silk fibroin protein-templated gold nanoclusters for in vivo fluorescence imaging.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2025Article
- Dye-Based Fluorescent Organic Nanoparticles, New Promising Tools for Optogenetics.Advanced healthcare materials · 2025Article
60 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Speed, resolution and sensitivity of today's fluorescence bioimaging can be drastically improved by fluorescent nanoparticles (NPs) that are many-fold brighter than organic dyes and fluorescent proteins. While the field is currently dominated by inorganic NPs, notably quantum dots (QDs), fluorescent polymer NPs encapsulating large quantities of dyes (dye-loaded NPs) have emerged recently as an attractive alternative. These new nanomaterials, inspired from the fields of polymeric drug delivery vehicles and advanced fluorophores, can combine superior brightness with biodegradability and low toxicity. Here, we describe the strategies for synthesis of dye-loaded polymer NPs by emulsion polymerization and assembly of pre-formed polymers. Superior brightness requires strong dye loading without aggregation-caused quenching (ACQ). Only recently several strategies of dye design were proposed to overcome ACQ in polymer NPs: aggregation induced emission (AIE), dye modification with bulky side groups and use of bulky hydrophobic counterions. The resulting NPs now surpass the brightness of QDs by ≈10-fold for a comparable size, and have started reaching the level of the brightest conjugated polymer NPs. Other properties, notably photostability, color, blinking, as well as particle size and surface chemistry are also systematically analyzed. Finally, major and emerging applications of dye-loaded NPs for in vitro and in vivo imaging are reviewed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.