ArticleCritical care medicine2016
Application of a Framework to Assess the Usefulness of Alternative Sepsis Criteria.
Article in Critical care medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed.
- Performance of a Sepsis Prediction Model Across Different Sepsis Definitions.JAMA network open · 2026Article
- Associations between Organ Dysfunction Scoring Systems and Dysregulated Host Responses in Adults with Severe Infection in Uganda: A Prospective Cohort Study.The American journal of tropical medicine and hygiene · 2025Article
- Unsupervised clustering for sepsis identification in large-scale patient data: a model development and validation study.Intensive care medicine experimental · 2025Article
- Development and validation of a screening tool for sepsis without laboratory results in the emergency department: a machine learning study.EClinicalMedicine · 2025Article
- Reassessing sepsis research: new clues for old players and new players for an old symptom to improve patient outcomes.EXCLI journal · 2025Review
- Comparative Analyses of the Impact of Different Criteria for Sepsis Diagnosis on Outcome in Patients with Spontaneous Subarachnoid Hemorrhage.Journal of clinical medicine · 2022Article
- Comparison between machine learning methods for mortality prediction for sepsis patients with different social determinants.BMC medical informatics and decision making · 2022Article
- Developing a shared sepsis data infrastructure: a systematic review and concept map to FHIR.NPJ digital medicine · 2022Article
- Ground truth labels challenge the validity of sepsis consensus definitions in critical illness.Journal of translational medicine · 2022Article
- Measurement of Sepsis in a National Cohort Using Three Different Methods to Define Baseline Organ Function.Annals of the American Thoracic Society · 2021Article
- Evaluating Pediatric Sepsis Definitions Designed for Electronic Health Record Extraction and Multicenter Quality Improvement.Critical care medicine · 2020Observational
- Leveraging electronic health record data to improve sepsis surveillance.BMJ quality & safety · 2020Article
- External validity of Adult Sepsis Event's simplified eSOFA criteria: a retrospective analysis of patients with confirmed infection in China.Annals of intensive care · 2020Article
- Sepsis trends: increasing incidence and decreasing mortality, or changing denominator?Journal of thoracic disease · 2020Review
- Identification of Pediatric Sepsis for Epidemiologic Surveillance Using Electronic Clinical Data.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2020Observational
- Article
- Correlation of Redox Status with Procalcitonin and C-reactive Protein in Septic Patients.Oxidative medicine and cellular longevity · 2020Article
- A National Approach to Pediatric Sepsis Surveillance.Pediatrics · 2019Article
- Comparison of Automated Sepsis Identification Methods and Electronic Health Record-based Sepsis Phenotyping: Improving Case Identification Accuracy by Accounting for Confounding Comorbid Conditions.Critical care explorations · 2019Article
- Accuracy of Quick Sequential Organ Failure Assessment Score to Predict Sepsis Mortality in 121 Studies Including 1,716,017 Individuals: A Systematic Review and Meta-Analysis.Critical care explorations · 2019Review
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
The current definition of sepsis is life-threatening, acute organ dysfunction secondary to a dysregulated host response to infection. Criteria to operationalize this definition can be judged by six domains of usefulness (reliability, content, construct and criterion validity, measurement burden, and timeliness). The relative importance of these six domains depends on the intended purpose for the criteria (clinical care, basic and clinical research, surveillance, or quality improvement [QI] and audit). For example, criteria for clinical care should have high content and construct validity, timeliness, and low measurement burden to facilitate prompt care. Criteria for surveillance or QI/audit place greater emphasis on reliability across individuals and sites and lower emphasis on timeliness. Criteria for clinical trials require timeliness to ensure prompt enrollment and reasonable reliability but can tolerate high measurement burden. Basic research also tolerates high measurement burden and may not need stability over time. In an illustrative case study, we compared examples of criteria designed for clinical care, surveillance and QI/audit among 396,241 patients admitted to 12 academic and community hospitals in an integrated health system. Case rates differed four-fold and mortality three-fold. Predictably, clinical care criteria, which emphasized timeliness and low burden and therefore used vital signs and routine laboratory tests, had the greater case identification with lowest mortality. QI/audit criteria, which emphasized reliability and criterion validity, used discharge information and had the lowest case identification with highest mortality. Using this framework to identify the purpose and apply domains of usefulness can help with the evaluation of existing sepsis diagnostic criteria and provide a roadmap for future work.
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