ArticlePloS one2016
Emx1 Is Required for Neocortical Area Patterning.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 13 citations in OpenAlex.
- A polarized FGF8 source specifies frontotemporal signatures in spatially oriented cell populations of cortical assembloids.Nature methods · 2024Article
- Genetic Regulation of Vertebrate Forebrain Development by Homeobox Genes.Frontiers in neuroscience · 2022Review
- Adult glut3 homozygous null mice survive to demonstrate neural excitability and altered neurobehavioral responses reminiscent of neurodevelopmental disorders.Experimental neurology · 2021Article
- Transcriptomic and epigenomic dynamics associated with development of human iPSC-derived GABAergic interneurons.Human molecular genetics · 2020Article
- How the Barrel Cortex Became a Working Model for Developmental Plasticity: A Historical Perspective.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Satb2 is required for the regionalization of retrosplenial cortex.Cell death and differentiation · 2020Article
- Segregated expressions of autism risk genes Cdh11 and Cdh9 in autism-relevant regions of developing cerebellum.Molecular brain · 2019Article
- Dendritic and Synaptic Degeneration in Pyramidal Neurons of the Sensorimotor Cortex in Neonatal Mice With Kaolin-Induced Hydrocephalus.Frontiers in neuroanatomy · 2019Article
- Impact of thalamocortical input on barrel cortex development.Neuroscience · 2018Review
- Deciphering the Role ofFrontiers in molecular neuroscience · 2016Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Establishing appropriate area patterning in the neocortex is a critical developmental event, and transcription factors whose expression is graded across the developing neural axes have been implicated in this process. While previous reports suggested that the transcription factor Emx1 does not contribute to neocortical area patterning, those studies were performed at perinatal ages prior to the emergence of primary areas. We therefore examined two different Emx1 deletion mouse lines once primary areas possess mature features. Following the deletion of Emx1, the frontal and motor areas were expanded while the primary visual area was reduced, and overall the areas shifted posterio-medially. This patterning phenotype was consistent between the two Emx1 deletion strategies. The present study demonstrates that Emx1 is an area patterning transcription factor and is required for the specification of the primary visual area.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.