Evidence map›Paper›PMID 26901523›Full record

Trial reportPloS one2016

Polymorphisms in B Cell Co-Stimulatory Genes Are Associated with IgG Antibody Responses against Blood-Stage Proteins of Plasmodium vivax.

Gustavo C Cassiano, Adriana A C Furini, Marcela P Capobianco, Luciane M Storti-Melo, Maristela G Cunha, Flora S Kano, Luzia H Carvalho, Irene S Soares, Sidney E Santos, Marinete M Póvoa and 1 more

Open access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
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  4. Microorganisms · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 1 country.

Gustavo C CassianoDepartment of Biology, São Paulo State University (Universidade Estadual Paulista - UNESP), São José do Rio Preto, state of São Paulo (SP), Brazil.
Adriana A C FuriniDepartment of Dermatologic, Infectious, and Parasitic Diseases, College of Medicine of São José do Rio Preto, São José do Rio Preto, SP, Brazil.
Marcela P CapobiancoDepartment of Biology, São Paulo State University (Universidade Estadual Paulista - UNESP), São José do Rio Preto, state of São Paulo (SP), Brazil.
Luciane M Storti-MeloDepartment of Biology, Federal University of Sergipe, Aracaju, Sergipe, Brazil.
Maristela G CunhaLaboratório of Microbiology and Immunology, Institute of Biological Sciences, Federal University of Pará (Universidade Federal do Pará - UFPA), Belém, state of Pará (PA), Brazil.
Flora S KanoLaboratory of Malaria, René Rachou Research Center, Oswaldo Cruz Foundation, Belo Horizonte, state of Minas Gerais (MG), Brazil.
Luzia H CarvalhoLaboratory of Malaria, René Rachou Research Center, Oswaldo Cruz Foundation, Belo Horizonte, state of Minas Gerais (MG), Brazil.
Irene S SoaresDepartment of Clinical and Toxicological Analyses, Faculty of Pharmaceutical Sciences, University of São Paulo (Universidade de São Paulo - USP), São Paulo, SP, Brazil.
Sidney E SantosLaboratory of Human and Medical Genetics, Federal University of Pará, Belém, PA, Brazil.
Marinete M PóvoaLaboratory of Basic Research in Malaria, Section of Parasitology, Evandro Chagas Institute, Belém, PA, Brazil.
Ricardo L D MachadoDepartment of Biology, São Paulo State University (Universidade Estadual Paulista - UNESP), São José do Rio Preto, state of São Paulo (SP), Brazil.
Universidade Estadual Paulista (Unesp) · BRFundação Oswaldo Cruz · BRUniversidade Federal do Pará · BRFaculdade de Medicina de São José do Rio Preto · BRInstituto Evandro Chagas · BRUniversidade de São Paulo · BRUniversidade Federal de Sergipe · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The development of an effective immune response can help decrease mortality from malaria and its clinical symptoms. However, this mechanism is complex and has significant inter-individual variation, most likely owing to the genetic contribution of the human host. Therefore, this study aimed to investigate the influence of polymorphisms in genes involved in the costimulation of B-lymphocytes in the naturally acquired humoral immune response against proteins of the asexual stage of Plasmodium vivax. A total of 319 individuals living in an area of malaria transmission in the Brazilian Amazon were genotyped for four SNPs in the genes CD40, CD40L, BLYS and CD86. In addition, IgG antibodies against P. vivax apical membrane antigen 1 (PvAMA-1), Duffy binding protein (PvDBP) and merozoite surface protein 1 (PvMSP-119) were detected by ELISA. The SNP BLYS -871C>T was associated with the frequency of IgG responders to PvAMA-1 and PvMSP-119. The SNP CD40 -1C>T was associated with the IgG response against PvDBP, whereas IgG antibody titers against PvMSP-119 were influenced by the polymorphism CD86 +1057G>A. These data may help to elucidate the immunological aspects of vivax malaria and consequently assist in the design of malaria vaccines.

Indexed as

Antigens, CDMalaria, VivaxAdolescentAdultAgedAntibodies, ProtozoanFemaleHumansImmunoglobulin GMaleMiddle AgedPlasmodium vivaxPolymorphism, Single NucleotideProtozoan ProteinsAntibodies, ProtozoanAntigens, CDImmunoglobulin GProtozoan Proteins

Identifiers

PMID26901523
PMCPMC4763038
OpenAlexW2415681198

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.