Evidence map›Paper›PMID 26901431›Full record

ArticlePloS one2016

Venous Thromboembolism and Cerebrovascular Events in Patients with Giant Cell Arteritis: A Population-Based Retrospective Cohort Study.

Alberto Lo Gullo, Matthew J Koster, Cynthia S Crowson, Ashima Makol, Steven R Ytterberg, Antonino Saitta, Carlo Salvarani, Eric L Matteson, Kenneth J Warrington

Abstract read
In one paragraph

Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Thromboembolic events in giant cell arteritis: a scoping review.Annals of medicine and surgery (2012) · 2026
    Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Do We Have a Culprit? An Association of Giant Cell Arteritis with Pulmonary Embolism.European journal of case reports in internal medicine · 2022
    Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Alberto Lo GulloDepartment of Clinical and Experimental Medicine, University of Messina, Messina ME, Italy.
Matthew J KosterDepartment of Medicine, Division of Rheumatology, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America.
Cynthia S CrowsonDepartment of Medicine, Division of Rheumatology, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America.
Ashima MakolDepartment of Medicine, Division of Rheumatology, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America.
Steven R YtterbergDepartment of Medicine, Division of Rheumatology, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America.
Antonino SaittaDepartment of Clinical and Experimental Medicine, University of Messina, Messina ME, Italy.
Carlo SalvaraniDepartment of Internal Medicine, Rheumatology Unit, Azienda Ospedaliera ASMN, Reggio Emilia, Italy.
Eric L MattesonDepartment of Medicine, Division of Rheumatology, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America.
Kenneth J WarringtonDepartment of Medicine, Division of Rheumatology, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America.

Funding

Mayo Clinic Center for Translational Science ActivitiesUL1TR000135 · NCATS · MAYO CLINIC ROCHESTER · PI KHOSLA, SUNDEEP · 2012 to 2015
$41.2M
Rochester Epidemiology ProjectR01AG034676 · NIA · MAYO CLINIC ROCHESTER · PI ROCCA, WALTER A, ST SAUVER, JENNIFER LYNN · 2010 to 2019
$9.5M
NCATS NIH HHS UL1 TR000135NIA NIH HHS R01 AG034676NIA NIH HHS R01AG034676
6 · The paper itself

Abstract

objectiveTo investigate the incidence of venous thromboembolism (VTE) and cerebrovascular events in a community-based incidence cohort of patients with giant cell arteritis (GCA) compared to the general population.

methodsA population-based inception cohort of patients with incident GCA between January 1, 1950 and December 31, 2009 in Olmsted County, Minnesota and a cohort of non-GCA subjects from the same population were assembled and followed until December 31, 2013. Confirmed VTE and cerebrovascular events were identified through direct medical record review.

resultsThe study population included 244 patients with GCA with a mean ± SD age at diagnosis of 76.2 ± 8.2 years (79% women) and an average length of follow-up of 10.2 ± 6.8 years. Compared to non-GCA subjects of similar age and sex, patients diagnosed with GCA had a higher incidence (%) of amaurosis fugax (cumulative incidence ± SE: 2.1 ± 0.9 versus 0, respectively; p = 0.014) but similar rates of stroke, transient ischemic attack (TIA), and VTE. Among patients with GCA, neither baseline characteristics nor laboratory parameters at diagnosis reliably predicted risk of VTE or cerebrovascular events.

conclusionIn this population-based study, the incidence of VTE, stroke and TIA was similar in patients with GCA compared to non-GCA subjects.

Indexed as

Giant Cell ArteritisStrokeVenous ThromboembolismAgedAged, 80 and overAge FactorsAmaurosis FugaxFemaleFollow-Up StudiesHumansIncidenceMaleRetrospective StudiesSex Factors

Identifiers

PMID26901431
PMCPMC4763510

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.