ArticleInternational journal of molecular sciences2016
Metabolic Activity of Radish Sprouts Derived Isothiocyanates in Drosophila melanogaster.
Article in International journal of molecular sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- Human, Animal and Plant Health Benefits of Glucosinolates and Strategies for Enhanced Bioactivity: A Systematic Review.Molecules (Basel, Switzerland) · 2020Pooled it
- Integrated transcriptomic and 16S rRNA analyses reveal colon and brain barrier-preserving effects of red radish (Raphanus sativus L.) sprout supplementation in high-fat diet-fed mice.Genes & genomics · 2026Article
- Glucosinolate-Myrosinase Formulations for Adult Obesity: Towards Next Generation of Bioactive Therapies.Foods (Basel, Switzerland) · 2025Article
- Comprehensive genomic and functional characterization of a phytoplasma associated with root retardation, early bolting, witches'-broom, and phyllody in daikon (Frontiers in microbiology · 2025Article
- Composition, Anti-Diabetic, and Antioxidant Potential ofMolecules (Basel, Switzerland) · 2024Article
- Evaluation of Climate Change Impacts on the Potential Distribution of Wild Radish in East Asia.Plants (Basel, Switzerland) · 2023Article
- Review
- Effects of Glucosinolate-Enriched Red Radish (ACS omega · 2023Article
- Effect of Hot- and Cold-Water Treatment on Broccoli Bioactive Compounds, Oxidative Stress Parameters and Biological Effects of Their Extracts.Plants (Basel, Switzerland) · 2023Article
- Root Vegetables-Composition, Health Effects, and Contaminants.International journal of environmental research and public health · 2022Review
- Exposure to Salinity and Light Spectra Regulates Glucosinolates, Phenolics, and Antioxidant Capacity ofAntioxidants (Basel, Switzerland) · 2021Article
- Germinated Buckwheat: Effects of Dehulling on Phenolics Profile and Antioxidant Activity of Buckwheat Seeds.Foods (Basel, Switzerland) · 2021Article
- Review
- Development of HPLC Method for Quantification of Sinigrin fromMolecules (Basel, Switzerland) · 2020Article
- Functional Characterization of Gomisin N in High-Fat-InducedInternational journal of molecular sciences · 2020Article
- Functional Ingredients FromInternational journal of molecular sciences · 2020Review
- The combined effects of ultrasound and lactic acid in inactivating microorganisms on fresh radish (Food science & nutrition · 2020Article
- Alpha Glucosidase Inhibitory Activities of Plants with Focus on Common Vegetables.Plants (Basel, Switzerland) · 2019Review
- Sorting out the Value of Cruciferous Sprouts as Sources of Bioactive Compounds for Nutrition and Health.Nutrients · 2019Review
- Deciphering the Nutraceutical Potential ofNutrients · 2019Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We used Drosophila melanogaster as a model system to study the absorption, metabolism and potential health benefits of plant bioactives derived from radish sprouts (Raphanus sativus cv. Rambo), a Brassicaceae species rich in glucosinolates and other phytochemicals. Flies were subjected to a diet supplemented with lyophilized radish sprouts (10.6 g/L) for 10 days, containing high amounts of glucoraphenin and glucoraphasatin, which can be hydrolyzed by myrosinase to the isothiocyanates sulforaphene and raphasatin, respectively. We demonstrate that Drosophila melanogaster takes up and metabolizes isothiocyanates from radish sprouts through the detection of the metabolite sulforaphane-cysteine in fly homogenates. Moreover, we report a decrease in the glucose content of flies, an upregulation of spargel expression, the Drosophila homolog of the mammalian PPARγ-coactivator 1 α, as well as the inhibition of α-amylase and α-glucosidase in vitro. Overall, we show that the consumption of radish sprouts affects energy metabolism in Drosophila melanogaster which is reflected by lower glucose levels and an increased expression of spargel, a central player in mitochondrial biogenesis. These processes are often affected in chronic diseases associated with aging, including type II diabetes mellitus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.