ArticleMolecules (Basel, Switzerland)2016
Multicomponent Analysis of the Differential Induction of Secondary Metabolite Profiles in Fungal Endophytes.
Article in Molecules (Basel, Switzerland), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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Who cites it
34 citing papers in PubMed, 54 citations in OpenAlex.
- Sulphopreussomerins: Sulfur-Containing Preussomerins Isolated from the Marine-Derived Fungus Pyrenochaetopsis indica.Journal of natural products · 2026Article
- Effect of epigenetic modulation on metabolites from endophytes isolated from Embelia ribes.International microbiology : the official journal of the Spanish Society for Microbiology · 2026Article
- Revolutionizing microbial treasure troves: innovative strategies for natural products discovery.Natural products and bioprospecting · 2026Review
- Article
- Structure and Fungicidal Activity of Secondary Metabolites Isolated fromJournal of fungi (Basel, Switzerland) · 2024Article
- Endophytic fungi: A future prospect for breast cancer therapeutics and drug development.Heliyon · 2024Review
- The hidden treasures in endophytic fungi: a comprehensive review on the diversity of fungal bioactive metabolites, usual analytical methodologies, and applications.Archives of microbiology · 2024Review
- Epigenetic Induction of Secondary Metabolites Production in Endophytic FungiMicroorganisms · 2023Article
- Recent Advances in Search of Bioactive Secondary Metabolites from Fungi Triggered by Chemical Epigenetic Modifiers.Journal of fungi (Basel, Switzerland) · 2023Review
- Comoclathrin, a novel potent skin-whitening agent produced by endophytic Comoclathris strains associated with Andalusia desert plants.Scientific reports · 2022Article
- Metals-triggered compound CDPDP exhibits anti-arthritic behavior by downregulating the inflammatory cytokines, and modulating the oxidative storm in mice models with extensive ADMET, docking and simulation studies.Frontiers in pharmacology · 2022Article
- Fungal Endophytes: A Promising Frontier for Discovery of Novel Bioactive Compounds.Journal of fungi (Basel, Switzerland) · 2021Review
- Metabolomic Analysis of The Chemical Diversity of South Africa Leaf Litter Fungal Species Using an Epigenetic Culture-Based Approach.Molecules (Basel, Switzerland) · 2021Article
- Reproductive development and genetic structure of the mycoheterotrophic orchid Pogoniopsis schenckii Cogn.BMC plant biology · 2021Article
- Bioactive Compounds from Mangrove Endophytic Fungus and Their Uses for Microorganism Control.Journal of fungi (Basel, Switzerland) · 2021Review
- Metabolomic profiling, biological evaluation ofRSC advances · 2021Article
- Profiling Analysis of Volatile and Non-volatile Compounds inFrontiers in nutrition · 2021Article
- Epigenetic Modifiers Revamp Secondary Metabolite Production in EndophyticFrontiers in microbiology · 2021Article
- Evaluation of DNA Methylation Changes by CRED-RA Analysis Following Prednisone Treatment of Endophyte,Indian journal of microbiology · 2020Article
- Chromatin-dependent regulation of secondary metabolite biosynthesis in fungi: is the picture complete?FEMS microbiology reviews · 2019Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Small molecule histone deacetylase (HDAC) and DNA methyltransferase (DNMT) inhibitors are commonly used to perturb the production of fungal metabolites leading to the induction of the expression of silent biosynthetic pathways. Several reports have described the variable effects observed in natural product profiles in fungi treated with HDAC and DNMT inhibitors, such as enhanced chemical diversity and/or the induction of new molecules previously unknown to be produced by the strain. Fungal endophytes are known to produce a wide variety of secondary metabolites (SMs) involved in their adaptation and survival within higher plants. The plant-microbe interaction may influence the expression of some biosynthetic pathways, otherwise cryptic in these fungi when grown in vitro. The aim of this study was to setup a systematic approach to evaluate and identify the possible effects of HDAC and DNMT inhibitors on the metabolic profiles of wild type fungal endophytes, including the chemical identification and characterization of the most significant SMs induced by these epigenetic modifiers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.