ArticleMolecules (Basel, Switzerland)2016
Synthesis and Structure-Activity Relationships of Imidazole-Coumarin Conjugates against Hepatitis C Virus.
Article in Molecules (Basel, Switzerland), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 35 citations in OpenAlex.
- 6-Chlorocoumarin Conjugates with Nucleobases and Nucleosides as Potent Anti-Hepatitis C Virus Agents.Molecules (Basel, Switzerland) · 2025Article
- Biological evaluation of novel amidino substituted coumarin-benzazole hybrids as promising therapeutic agents.RSC medicinal chemistry · 2023Article
- Discovery of Bis-Imidazoline Derivatives as New CXCR4 Ligands.Molecules (Basel, Switzerland) · 2023Article
- Synthesis of esters and amides of 2-aryl-1-hydroxy-4-methyl-1H-imidazole-5-carboxylic acids and study of their antiviral activity against orthopoxviruses.Bioorganic & medicinal chemistry letters · 2023Article
- Computer-Aided Design and Synthesis of (Functionalized quinazoline)-(α-substituted coumarin)-arylsulfonate Conjugates against Chikungunya Virus.International journal of molecular sciences · 2022Article
- Microwave spectra, molecular geometries, and internal rotation of CHPhysical chemistry chemical physics : PCCP · 2022Article
- Pharmacological perspectives and molecular mechanisms of coumarin derivatives against virus disease.Genes & diseases · 2022Review
- An Overview of Coumarin as a Versatile and Readily Accessible Scaffold with Broad-Ranging Biological Activities.International journal of molecular sciences · 2020Review
- Coumarin: An emerging antiviral agent.Heliyon · 2020Article
- Synthesis of 3-(Imidazo[2,1-Molecules (Basel, Switzerland) · 2019Article
- Transition metal-free oxidative and deoxygenative C-H/C-Li cross-couplings of 2Beilstein journal of organic chemistry · 2018Article
- Therapeutic potential of coumarins as antiviral agents.European journal of medicinal chemistry · 2016Review
- Design, Synthesis and Antifungal Activity of Coumarin Ring-Opening Derivatives.Molecules (Basel, Switzerland) · 2016Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A series of new conjugated compounds with a -SCH₂- linkage were synthesized by chemical methods from imidazole and coumarin derivatives. The experimental results indicate that of the twenty newly synthesized imidazole-coumarin conjugates, three of them exhibited appealing EC50 values (5.1-8.4 μM) and selective indices >20 against hepatitis C virus. Their potency and selectivity were increased substantially by modification of their structure with two factors: imidazole nucleus with a hydrogen atom at the N(1) position and coumarin nucleus with a substituent, such as Cl, F, Br, Me, and OMe. These guidelines provide valuable information for further development of conjugated compounds as anti-viral agents.
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