ReviewCurrent opinion in microbiology2016
Bacillus subtilis extracytoplasmic function (ECF) sigma factors and defense of the cell envelope.
Review in Current opinion in microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
86 citing papers in PubMed, 134 citations in OpenAlex.
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- Matrix plasticity and the molecular basis of extracellular filament assembly inScience advances · 2026Article
- Pleiotropic roles of elongation factor P inMicrobiology spectrum · 2026Article
- Role of Stress Response Genes in Resistance and Germination ofMicroorganisms · 2026Article
- Persistent Gaps in the Ultimate Mechanisms of Antimicrobial-Induced Bacterial Killing.Antibiotics (Basel, Switzerland) · 2026Review
- The Dual Role of RsiP in Regulating Virulence and Host Adaptation inPathogens (Basel, Switzerland) · 2026Article
- Discovery of Novel c-di-GMP-Related Genes inPathogens (Basel, Switzerland) · 2026Article
- Structural basis of pausing during transcription initiation in mycobacterium tuberculosis.Nature communications · 2026Article
- The phage shock protein response of Listeria monocytogenes influences tolerance to the multipeptide bacteriocin garvicin KS.Applied microbiology and biotechnology · 2026Article
- Differential coping strategies exerted by biofilm and planktonic cells ofMicrobiology spectrum · 2026Article
- ThebioRxiv : the preprint server for biology · 2025Article
- The avermectin, emamectin benzoate, kills gram-positive bacteria and targets the cell envelope ofMicrobiology spectrum · 2025Article
- A mutation in RNA polymerase imparts resistance to β-lactams by preventing dysregulation of amino acid and nucleotide metabolism.Cell reports · 2025Article
- The extracytoplasmic sigma factor σScientific reports · 2025Article
- The CssRS two-component system of Bacillus subtilis contributes to teicoplanin and polymyxin B response.Folia microbiologica · 2025Article
- Adaptive laboratory evolution for improved tolerance of vitamin K in Bacillus subtilis.Applied microbiology and biotechnology · 2024Article
- Bacillus subtilis uses the SigM signaling pathway to prioritize the use of its lipid carrier for cell wall synthesis.PLoS biology · 2024Article
- TheJournal of bacteriology · 2024Article
26 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Bacillus subtilis provides a model for investigation of the bacterial cell envelope, the first line of defense against environmental threats. Extracytoplasmic function (ECF) sigma factors activate genes that confer resistance to agents that threaten the integrity of the envelope. Although their individual regulons overlap, σ(W) is most closely associated with membrane-active agents, σ(X) with cationic antimicrobial peptide resistance, and σ(V) with resistance to lysozyme. Here, I highlight the role of the σ(M) regulon, which is strongly induced by conditions that impair peptidoglycan synthesis and includes the core pathways of envelope synthesis and cell division, as well as stress-inducible alternative enzymes. Studies of these cell envelope stress responses provide insights into how bacteria acclimate to the presence of antibiotics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.