Evidence map›Paper›PMID 26900787›Full record

ArticleBiomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals2016

Infant birth weight and third trimester maternal plasma markers of vascular integrity: the MIREC study.

Premkumari Kumarathasan, Renaud Vincent, Agnieszka Bielecki, Erica Blais, Katrin Blank, Dharani Das, Subramanian Karthikeyan, Sabit Cakmak, Mandy Fisher, Tye Arbuckle and 1 more

Abstract read
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In one paragraph

Article in Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Premkumari Kumarathasana Analytical Biochemistry and Proteomics Laboratory, Environmental Health Science and Research Bureau, Healthy Environments and Consumer Safety Branch, Health Canada , Ottawa , ON , Canada .
Renaud Vincentb Inhalation Toxicology Laboratory, Environmental Health Science and Research Bureau, Healthy Environments and Consumer Safety Branch, Health Canada , Ottawa , ON , Canada .
Agnieszka Bieleckia Analytical Biochemistry and Proteomics Laboratory, Environmental Health Science and Research Bureau, Healthy Environments and Consumer Safety Branch, Health Canada , Ottawa , ON , Canada .
Erica Blaisa Analytical Biochemistry and Proteomics Laboratory, Environmental Health Science and Research Bureau, Healthy Environments and Consumer Safety Branch, Health Canada , Ottawa , ON , Canada .
Katrin Blanka Analytical Biochemistry and Proteomics Laboratory, Environmental Health Science and Research Bureau, Healthy Environments and Consumer Safety Branch, Health Canada , Ottawa , ON , Canada .
Dharani Dasa Analytical Biochemistry and Proteomics Laboratory, Environmental Health Science and Research Bureau, Healthy Environments and Consumer Safety Branch, Health Canada , Ottawa , ON , Canada .
Subramanian Karthikeyanb Inhalation Toxicology Laboratory, Environmental Health Science and Research Bureau, Healthy Environments and Consumer Safety Branch, Health Canada , Ottawa , ON , Canada .
Sabit Cakmakc Population Studies Division, Environmental Health Science and Research Bureau, Healthy Environments and Consumer Safety Branch, Health Canada , Ottawa , ON , Canada , and.
Mandy Fisherc Population Studies Division, Environmental Health Science and Research Bureau, Healthy Environments and Consumer Safety Branch, Health Canada , Ottawa , ON , Canada , and.
Tye Arbucklec Population Studies Division, Environmental Health Science and Research Bureau, Healthy Environments and Consumer Safety Branch, Health Canada , Ottawa , ON , Canada , and.
William Fraserd Department of Obstetrics and Gynecology , University of Sherbrooke , Sherbrooke , QC , Canada.

Funding

Canadian Institutes of Health Research MOP-81285
6 · The paper itself

Abstract

backgroundThere is paucity of information on mechanisms constituting adverse birth outcomes. We assessed here the relationship between vascular integrity and adverse birth effects. METHODS AND

resultsThird trimester maternal plasma (n = 144) from the Maternal-Infant Research on Environmental Chemicals Study (MIREC) was analysed for vascular, inflammatory and oxidative stress markers by HPLC-fluorescence, protein array and EIA method. Analysis of the <25th and >75th percentile birth weight subgroups revealed markers associated with birth weight (ETs, MMP-9, VEGF, and 8-isoPGF-2α) and gestational age (ET-1, MMP-2, and VEGF).

conclusionsMechanistic insights into adverse birth outcome pathways can be achieved by integrating information on multiple biomarkers, physiology using systems biology approach.

Indexed as

Birth WeightOxidative StressAdultBiomarkersF2-IsoprostanesFemaleGestational AgeHumansInfantMatrix Metalloproteinase 2Matrix Metalloproteinase 9PregnancyPregnancy OutcomePregnancy Trimester, ThirdVascular Endothelial Growth Factor ABiomarkersF2-IsoprostanesMatrix Metalloproteinase 2Matrix Metalloproteinase 9Vascular Endothelial Growth Factor AGestational ageinfant birth weightmaternal plasma biomarkersoxidative stressvascular function

Identifiers

PMID26900787
PMCPMC4841026

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.