ArticleEarly human development2016
Improved survival and neurodevelopmental outcomes among extremely premature infants born near the limit of viability.
Article in Early human development, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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The trial behind it
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Survival outcomes among periviable infants: a systematic review and meta-analysis comparing different income countries and time periods.Frontiers in public health · 2024Pooled it
- Global prevalence of long-term neurodevelopmental impairment following extremely preterm birth: a systematic literature review.The Journal of international medical research · 2021Pooled it
- Autism screening and diagnostic outcomes among toddlers born preterm.Developmental medicine and child neurology · 2025Article
- Ethical considerations regarding the treatment of extremely preterm infants at the limit of viability: a comprehensive review.European journal of pediatrics · 2025Review
- Two-year neurodevelopmental outcome in children born extremely preterm: the EPI-DAF study.Archives of disease in childhood. Fetal and neonatal edition · 2022Article
- Longitudinal medical needs for periviable NICU survivors.Early human development · 2022Article
- Perspectives on Resuscitation Decisions at the Margin of Viability among Specialist Newborn Care Providers in Ghana and Ethiopia: A Qualitative Analysis.BMC pediatrics · 2022Article
- Transcutaneous carbon dioxide pattern and trend over time in preterm infants.Pediatric research · 2021Article
- Sildenafil administration improves right ventricular function on 4D flow MRI in young adults born premature.American journal of physiology. Heart and circulatory physiology · 2021Article
- Altered Right Ventricular Filling at Four-dimensional Flow MRI in Young Adults Born Prematurely.Radiology. Cardiothoracic imaging · 2021Article
- Dynamic FDG PET Imaging to Probe for Cardiac Metabolic Remodeling in Adults Born Premature.Journal of clinical medicine · 2021Article
- Developmental Trajectories in Very Preterm Born Children Up to 8 Years: A Longitudinal Cohort Study.Frontiers in pediatrics · 2021Article
- Bioethical Decisions in Neonatal Intensive Care: Neonatologists' Self-Reported Practices in Greek NICUs.International journal of environmental research and public health · 2020Article
- Changes in survival and neurodevelopmental outcomes of infants born at <25 weeks' gestation: a retrospective observational study in tertiary centres in Japan.BMJ paediatrics open · 2018Article
- Trends in Overall Mortality, and Timing and Cause of Death among Extremely Preterm Infants near the Limit of Viability.PloS one · 2017Article
- Monitoring Cerebral Oxygenation in Neonates: An Update.Frontiers in pediatrics · 2017Review
- Antenatal Exposure to Magnesium Sulfate Is Associated with Reduced Cerebellar Hemorrhage in Preterm Newborns.The Journal of pediatrics · 2016Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundInfants born near the limit of viability are at high risk for death or adverse neurodevelopmental outcomes. It is unclear whether these outcomes have improved over the past 15 years.
aimTo determine if death and neurodevelopmental impairment have declined over the past 15 years in infants born at 22 to 24 weeks' gestation. STUDY
designRetrospective cohort study. SUBJECTS: We identified infants born at 22 to 24 weeks' gestation in our center in two epochs: 1998-2004 (Epoch 1) and 2005-2011 (Epoch 2). OUTCOME MEASURES: The primary outcome, death or neurodevelopmental impairment, was evaluated at 17-25 months' corrected gestational age with neurologic exams and Bayley Scales of Infant Development. Perinatal characteristics, major morbidities, and outcomes were compared between epochs.
resultsBirth weight and gestational age were similar between 170 infants in Epoch 1 and 187 infants in Epoch 2. Mortality was significantly lower in Epoch 2, 55% vs. 42% (p=0.02). Among surviving infants, late-onset sepsis (p<0.01), bronchopulmonary dysplasia (p<0.01), and surgical necrotizing enterocolitis (p=0.04) were less common in Epoch 2. Neurodevelopmental impairment among surviving infants declined from 68% in Epoch 1 to 47% in Epoch 2, p=0.02. Odds of death or NDI were significantly lower in Epoch 2 vs. Epoch 1, OR=0.31 (95% confidence interval; 0.16, 0.58).
conclusionRisk of death or neurodevelopmental impairment decreased over time in infants born at 22 to 24 weeks' gestation.
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