ArticleMagnetic resonance in medicine2017
On-resonance variable delay multipulse scheme for imaging of fast-exchanging protons and semisolid macromolecules.
Article in Magnetic resonance in medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26 citing papers in PubMed, 41 citations in OpenAlex.
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- Does the magnetization transfer effect bias chemical exchange saturation transfer effects? Quantifying chemical exchange saturation transfer in the presence of magnetization transfer.Magnetic resonance in medicine · 2020Article
- Evaluation of cell transplant-mediated attenuation of diffuse injury in experimental autoimmune encephalomyelitis using onVDMP CEST MRI.Experimental neurology · 2020Article
- Altered d-glucose in brain parenchyma and cerebrospinal fluid of early Alzheimer's disease detected by dynamic glucose-enhanced MRI.Science advances · 2020Article
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- The effect of the mTOR inhibitor rapamycin on glucoCEST signal in a preclinical model of glioblastoma.Magnetic resonance in medicine · 2019Article
- GlucoCEST imaging with on-resonance variable delay multiple pulse (onVDMP) MRI.Magnetic resonance in medicine · 2019Article
- Separating fast and slow exchange transfer and magnetization transfer using off-resonance variable-delay multiple-pulse (VDMP) MRI.Magnetic resonance in medicine · 2018Article
- CEST, ASL, and magnetization transfer contrast: How similar pulse sequences detect different phenomena.Magnetic resonance in medicine · 2018Review
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
purposeTo develop an on-resonance variable delay multipulse (VDMP) scheme to image magnetization transfer contrast (MTC) and the chemical exchange saturation transfer (CEST) contrast of total fast-exchanging protons (TFP) with exchange rate above approximately 1 kHz.
methodsA train of high power binomial pulses was applied at the water resonance. The interpulse delay, called mixing time, was varied to observe its effect on the water signal reduction, allowing separation and quantification of MTC and CEST contributions as a result of their different proton transfer rates. The fast-exchanging protons in CEST and MTC are labeled together with the short T
resultsPhantom studies of selected metabolite solutions (glucose, glutamate, creatine, myo-inositol), bovine serum albumin (BSA), and hair conditioner show the capability of on-resonance VDMP to separate out exchangeable protons with exchange rates above 1 kHz. Quantitative MTC and TFP maps were acquired on healthy mouse brains using this method, showing strong gray/white matter contrast for the slowly transferring MTC protons, whereas the TFP map was more uniform across the brain but somewhat higher in gray matter.
conclusionsThe new method provides a simple way of imaging fast-exchanging protons and MTC components with a slow transfer rate. Magn Reson Med 77:730-739, 2017. © 2016 International Society for Magnetic Resonance in Medicine.
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