Evidence map›Paper›PMID 26900601›Full record

ArticleJCI insight2016

Blocking MHC class II on human endothelium mitigates acute rejection.

Parwiz Abrahimi, Lingfeng Qin, William G Chang, Alfred L M Bothwell, George Tellides, W Mark Saltzman, Jordan S Pober

Open access · goldAbstract read
In one paragraph

Article in JCI insight, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 78 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
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  7. Article
  8. Elucidating the role of S100A10 in CD8Cell death & disease · 2024
    Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Human Endothelial Colony-Forming Cells.Cold Spring Harbor perspectives in medicine · 2022
    Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Parwiz AbrahimiDepartment of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA.
Lingfeng QinDepartment of Surgery, Yale University School of Medicine, New Haven, Connecticut, USA.
William G ChangDepartment of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
Alfred L M BothwellDepartment of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA.
George TellidesDepartment of Surgery, Yale University School of Medicine, New Haven, Connecticut, USA.
W Mark SaltzmanDepartment of Biomedical Engineering, Yale University School of Medicine, New Haven, Connecticut, USA.
Jordan S PoberDepartment of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA.
Yale University · US

Funding

Yale Pathology Tissue Services Shared ResourceP30CA016359 · NCI · YALE UNIVERSITY · PI DAVID L RIMM · 1985 to 2026
$85.0M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007205 · NIGMS · YALE UNIVERSITY · PI KAZMIERCZAK, BARBARA I · 1985 to 2019
$42.9M
Presentation of Alloantigen by Human Vascular CellsR01HL051014 · NHLBI · YALE UNIVERSITY · PI MANES, THOMAS DAVID, POBER, JORDAN S · 1994 to 2019
$10.4M
Optimizing Therapeutic Revascularization by Endothelial Cell TransplantationR01HL085416 · NHLBI · YALE UNIVERSITY · PI POBER, JORDAN S, SALTZMAN, W. MARK · 2006 to 2019
$5.9M
PROTEINS OF THE ENDOTHELIAL CELL SURFACER01HL036003 · NHLBI · YALE UNIVERSITY · PI KLUGER, MARTIN S, POBER, JORDAN S · 1985 to 2015
$5.7M
Regulating Anti-Endothelial T Cell Responses in Graft ArteriosclerosisR01HL109455 · NHLBI · YALE UNIVERSITY · PI BOTHWELL, ALFRED LM, POBER, JORDAN S · 2011 to 2014
$2.5M
Modulation of vascular endothelial alloimmunogenicity by nanoparticle-mediated geF30AI112218 · NIAID · YALE UNIVERSITY · PI ABRAHIMI, PARWIZ · 2014 to 2016
$109k
NCI NIH HHS P30 CA016359NHLBI NIH HHS R01 HL036003NHLBI NIH HHS R01 HL051014NHLBI NIH HHS R01 HL085416NHLBI NIH HHS R01 HL109455NIAID NIH HHS F30 AI112218NIGMS NIH HHS T32 GM007205
6 · The paper itself

Abstract

Acute allograft rejection is mediated by host CD8

Indexed as

Endothelial CellsGraft RejectionHistocompatibility Antigens Class IIAnimalsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesHLA-DR AntigensHumansMiceT-Lymphocytes, CytotoxicHistocompatibility Antigens Class IIHLA-DR Antigens

Identifiers

PMID26900601
PMCPMC4756651
OpenAlexW2265387817

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.