Evidence map›Paper›PMID 26900494›Full record

ArticleAdvances in bioscience and biotechnology (Print)2015

The Role of DNA Mismatch Repair and Recombination in the Processing of DNA Alkylating Damage in Living Yeast Cells.

Hernan Flores-Rozas, Lahcen Jaafar, Ling Xia

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advances in bioscience and biotechnology (Print), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Yeast Rpn4 Links the Proteasome and DNA Repair viaInternational journal of molecular sciences · 2020
    Article
  4. Functional Interaction BetweenFrontiers in genetics · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Hernan Flores-Rozas *College of Pharmacy and Pharmaceutical Sciences, Florida A&M University, Tallahassee, USA.
Lahcen Jaafar *Institute of Molecular Medicine and Genetics, Georgia Regents University, Augusta, USA.
Ling Xia *Institute of Molecular Medicine and Genetics, Georgia Regents University, Augusta, USA.

Funding

THE PREVENTION OF B(A)P INDUCED CELL TRANSFORMATION BY ORGANOSULFUR COMPOUNDSG12RR003020 · NCRR · FLORIDA AGRICULTURAL AND MECHANICAL UNIV · PI DARLING-REED, SELINA FAITH · 1985 to 2011
$29.7M
Nanomedicine Center for Nucleoprotein MachinesPN2EY018244 · NEI · RICE UNIVERSITY · PI BAO, GANG · 2006 to 2015
$24.4M
Recruitment and HiringG12MD007582 · NIMHD · FLORIDA AGRICULTURAL AND MECHANICAL UNIV · PI SOLIMAN, KARAM F.A. · 2012 to 2017
$16.0M
Targeted Nanocarrier Combination Based Therapy for Lung CancerP20MD006738 · NIMHD · FLORIDA AGRICULTURAL AND MECHANICAL UNIV · PI SOLIMAN, KARAM F.A. · 2012 to 2016
$5.6M
NCRR NIH HHS G12 RR003020NEI NIH HHS PN2 EY018244NIMHD NIH HHS G12 MD007582NIMHD NIH HHS P20 MD006738
6 · The paper itself

Abstract

It is proposed that mismatch repair (MMR) mediates the cytotoxic effects of DNA damaging agents by exerting a futile repair pathway which leads to double strand breaks (DSBs). Previous reports indicate that the sensitivity of cells defective in homologous recombination (HR) to DNA alkylation is reduced by defects in MMR genes. We have assessed the contribution of different MMR genes to the processing of alkylation damage

Indexed as

DNA DamageDNA Mismatch RepairNon-Homologous End JoiningRecombination

Identifiers

PMID26900494
PMCPMC4758339

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.