Evidence map›Paper›PMID 26900485›Full record

ArticleEnvironmental epigenetics2016

Epigenetics-a potential mediator between air pollution and preterm birth.

Vania W Lin, Andrea A Baccarelli, Heather H Burris

Abstract read
In one paragraph

Article in Environmental epigenetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
  6. Review
  7. Prevention of Preterm Birth with Progesterone.Journal of clinical medicine · 2021
    Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. Necessity of Epigenetic Epidemiology Studies on the Carcinogenesis of Lung Cancer in Never Smokers.Journal of preventive medicine and public health = Yebang Uihakhoe chi · 2018
    Article
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Vania W LinChicago Medical School at Rosalind Franklin University of Medicine and Science, North Chicago, IL, 60064 USA; Department of Neonatology, Beth Israel Deaconess Medical Center & Division of Newborn Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, 02215 USA.
Andrea A BaccarelliDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, 02115 USA.
Heather H BurrisDepartment of Neonatology, Beth Israel Deaconess Medical Center & Division of Newborn Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, 02215 USA; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, 02115 USA.

Funding

Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI Marc G Weisskopf · 1985 to 2026
$44.6M
BPA, Phthalates & Stress: Mechanisms and Interactions for Childhood ObesityR01ES021357 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI BACCARELLI, ANDREA, WRIGHT, ROBERT O · 2012 to 2016
$3.3M
Epigenetic Mechanisms of PM-Mediated CVD RiskR01ES020836 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BACCARELLI, ANDREA, HOU, LIFANG · 2012 to 2016
$3.0M
Environment, Fetal Tissue DNA Methylation & BirthweightR01ES020268 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BACCARELLI, ANDREA, WRIGHT, ROBERT O · 2011 to 2013
$2.5M
Molecular and Epigenetic Mitochondriomics of Air Particles, Lead and CognitionR01ES021733 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI BACCARELLI, ANDREA · 2012 to 2015
$2.4M
The Toxic Environment and the Epigenetics of Fetal GrowthK23ES022242 · NIEHS · CHILDREN'S HOSP OF PHILADELPHIA · PI BURRIS, HEATHER HERSON · 2013 to 2017
$790k
Histone modifications and respiratory effects of traffic particle exposureR21ES020984 · NIEHS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BACCARELLI, ANDREA, HOU, LIFANG · 2012 to 2013
$455k
Micro-RNA Profiling and Cardiovascular Effects of Traffic Particle ExposureR21ES020010 · NIEHS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BACCARELLI, ANDREA, HOU, LIFANG · 2011 to 2012
$443k
Flame retardants, thyroid function, and psychomotor skills in childrenR21ES024841 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI BACCARELLI, ANDREA, TAKSER, LARISSA · 2015 to 2016
$363k
NIEHS NIH HHS K23 ES022242NIEHS NIH HHS P30 ES000002NIEHS NIH HHS R01 ES020268NIEHS NIH HHS R01 ES020836NIEHS NIH HHS R01 ES021357NIEHS NIH HHS R01 ES021733NIEHS NIH HHS R21 ES020010NIEHS NIH HHS R21 ES020984NIEHS NIH HHS R21 ES024841
6 · The paper itself

Abstract

Preterm birth is a major cause of infant morbidity and mortality and a potential risk factor for adult chronic disease. With over 15 million infants born preterm worldwide each year, preterm birth poses a global health concern. There is a possible association between air pollution and preterm birth, though studies have been inconsistent, likely due to variation in study design. How air pollution induces health effects is uncertain; however, studies have repeatedly demonstrated the effects of air pollution on epigenetic modifications. More recent evidence suggests that epigenetics may, in turn, be linked to preterm birth. Discovery of environmentally modifiable epigenetic processes connected to preterm birth may help to identify women at risk of preterm birth, and ultimately lead to development of new preterm birth prevention measures.

Indexed as

air pollutionDNA methylationepigeneticspregnancypreterm birth

Identifiers

PMID26900485
PMCPMC4760696

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.