ReviewThe Clinical biochemist. Reviews2015
Reporting Thyroid Function Tests in Pregnancy.
Review in The Clinical biochemist. Reviews, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Prenatal exposure to air pollution and maternal and fetal thyroid function: a systematic review of the epidemiological evidence.Environmental health : a global access science source · 2024Pooled it
- Association of Maternal Thyroid-stimulating Hormone Levels with Psychological Well-being, Sexual Function, and Quality of Life During Pregnancy.Reproductive sciences (Thousand Oaks, Calif.) · 2026Article
- First trimester of pregnancy TSH laboratory specific reference intervals established by an indirect method.Biochemia medica · 2026Observational
- Neighborhood deprivation and iodine levels influence air pollution effects on maternal thyroid function in early pregnancy.Environmental research · 2025Article
- Unmet Need for Completing the Antenatal Care Continuum Among Pregnant Women in Rural India: A Mixed-Methods Study.Cureus · 2025Article
- Subacute thyroiditis in pregnancy: a narrative review.Thyroid research · 2025Review
- Review
- Trimester-specific reference intervals for thyroid function parameters in pregnant Caucasian women using Roche platforms: a prospective study.Journal of endocrinological investigation · 2023Article
- Recommendations of the AGG (Working Group for Obstetrics, Department of Maternal Diseases) on How to Treat Thyroid Function Disorders in Pregnancy.Geburtshilfe und Frauenheilkunde · 2023Article
- Intensifying Iodine Deficiency Throughout Trimesters of Pregnancy in a Borderline Iodine-Sufficient Urban Area, Ankara, Turkey.Biological trace element research · 2022Article
- Serum glial fibrillary acidic protein as a biomarker of brain injury in premature neonates.Bosnian journal of basic medical sciences · 2022Article
- Serum Activin A as Brain Injury Biomarker in the First Three Days of Life. A Prospective Case-Control Longitudinal Study in Human Premature Neonates.Brain sciences · 2021Article
- A pathway level analysis of PFAS exposure and risk of gestational diabetes mellitus.Environmental health : a global access science source · 2021Review
- Associations of Exposure to Perfluoroalkyl Substances With Thyroid Hormone Concentrations and Birth Size.The Journal of clinical endocrinology and metabolism · 2020Article
- The Clinical Value and Variation of Antithyroid Antibodies during Pregnancy.Disease markers · 2020Review
- Pituitary Disease in Pregnancy: Special Aspects of Diagnosis and Treatment?Geburtshilfe und Frauenheilkunde · 2019Article
- Thyroid Disorders in Homozygous β-Thalassemia: Current Knowledge, Emerging Issues and Open Problems.Mediterranean journal of hematology and infectious diseases · 2019Review
- A 2018 Italian and Romanian Survey on Subclinical Hypothyroidism in Pregnancy.European thyroid journal · 2018Article
- Update on the Management of Thyroid Disease during Pregnancy.Endocrinology and metabolism (Seoul, Korea) · 2016Review
- Are TSH normal reference ranges adequate for pregnant women?Archives of endocrinology and metabolism · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While there is agreement that overt maternal hypothyroidism (serum thyroid stimulating hormone (TSH) >10 mIU/L) should be treated immediately, the evidence is mixed regarding the harm associated with subclinical hypothyroidism and the benefits of thyroxine replacement. The diagnosis of subclinical hypothyroidism rests on the recognition of an increased serum concentration of TSH which may be affected by many factors including gestational age, analytical method, the antibody status of the mother, ethnicity, iodine nutrition and even the time of day when the blood is collected. The 97.5(th) percentile of TSH at the end of the first trimester is commonly used as the upper boundary of normal in early pregnancy with a default value of 2.5 mIU/L specified in a number of recent clinical guidelines. There have now been numerous papers showing that a more realistic figure is between 3.0 and 4.0 mIU/L depending on the analytical method that is used. There are suggestions that ethnicity may also have a significant effect on TSH and FT4 reference limits in pregnancy.
Identifiers
26900190PMC4758281W2296558555What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.