Evidence map›Paper›PMID 26899879›Full record

ArticleNutrition, metabolism, and cardiovascular diseases : NMCD2016

Diet and adipose tissue distributions: The Multi-Ethnic Study of Atherosclerosis.

R V Shah, V L Murthy, M A Allison, J Ding, M Budoff, A C Frazier-Wood, J A C Lima, L Steffen, D Siscovick, K L Tucker and 5 more

Open access · greenAbstract read
In one paragraph

Article in Nutrition, metabolism, and cardiovascular diseases : NMCD, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 4 pooled it
5.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 4 syntheses or guidelines pooled it, 46 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Observational
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 13 institutions in 1 country.

R V ShahDepartment of Medicine, Cardiovascular Division, Beth Israel Deaconess Medical Center, 330 Brookline Ave., Boston, MA 02215, USA. Electronic address: rshah1@bidmc.harvard.edu.
V L MurthyDepartment of Medicine (Cardiovascular Medicine Division), University of Michigan, Ann Arbor, MI, USA; Department of Radiology (Nuclear Medicine Division), University of Michigan, Ann Arbor, MI, USA. Electronic address: vlmurthy@med.umich.edu.
M A AllisonDepartment of Family and Preventive Medicine, University of California, San Diego, La Jolla, CA, USA.
J DingWake Forest University School of Medicine, Winston-Salem, NC, USA.
M BudoffDepartment of Cardiology and Medicine, University of California - Los Angeles, Los Angeles, CA, USA.
A C Frazier-WoodUSDA/ARS Children's Nutrition Research Center, Baylor College of Medicine, Houston, TX, USA.
J A C LimaDepartment of Medicine, Division of Cardiology, Johns Hopkins University, Baltimore, MD, USA.
L SteffenUniversity of Minnesota School of Public Health, Minneapolis, MN, USA.
D SiscovickUniversity of Washington School of Public Health, Seattle, WA, USA.
K L TuckerUniversity of Massachusetts at Lowell School of Public Health, Lowell, MA, USA.
P OuyangDepartment of Medicine, Division of Cardiology, Johns Hopkins University, Baltimore, MD, USA.
S A AbbasiDepartment of Cardiology, Brown University, Providence, RI, USA.
K DanielsonDepartment of Medicine, Cardiovascular Division, Beth Israel Deaconess Medical Center, 330 Brookline Ave., Boston, MA 02215, USA.
M Jerosch-HeroldNoninvasive Cardiovascular Imaging Section, Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA; Department of Radiology, Brigham and Women's Hospital, Boston, MA, USA.
D MozaffarianTufts University School of Public Health, Boston, MA, USA. Electronic address: darius.mozaffarian@tufts.edu.
Beth Israel Deaconess Medical Center · USJohns Hopkins Medicine · USBrigham and Women's Hospital · USBrown University · USChildren's Nutrition Research Center at Baylor College of Medicine · USMichigan Medicine · USTufts University · USUniversity of California, Los Angeles · USUniversity of California, San Diego · USUniversity of Massachusetts Lowell · USUniversity of Minnesota · USUniversity of Washington · USWake Forest University · US

Funding

Institute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8M
Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2M
Abdominal Body Composition, Inflammation and Cardiovascular DiseaaseR01HL088451 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ALLISON, MATTHEW A · 2007 to 2011
$2.5M
Ventricular Size and Valve Calcification Measures by CTR01HL071739 · NHLBI · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI BUDOFF, MATTHEW J · 2003 to 2010
$2.0M
Cigarette Smoke and Susceptibility to Influenza InfectionR01HL095163 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JASPERS, ILONA, NOAH, TERRY L · 2009 to 2013
$2.0M
Pericardial fat and subclinical and clinical measures of coronary heart diseaseR01HL085323 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI DING, JINGZHONG · 2006 to 2009
$1.6M
Adjunctive Use of Apyrase to Fibrinolytic TherapyR44HL095169 · NHLBI · APT THERAPEUTICS, INC. · PI CHEN, RIDONG · 2012 to 2013
$1.3M
SUBCLINICAL CARDIOVASCULAR DISEASE STUDYN01HC095166 · HC · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI TRACY, RUSSELL P · 1999 to 2001
$758k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY-FIELD CENTERN01HC095162 · HC · JOHNS HOPKINS UNIVERSITY · PI SZKLO, MOYSES A · 1999 to 2000
$694k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC095161 · HC · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SHEA, STEVEN · 1999 to 2001
$642k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC095165 · HC · WAKE FOREST UNIVERSITY · PI BURKE, GREGORY L · 1999 to 2001
$616k
NCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1-TR-000040NCATS NIH HHS UL1 TR001079NCATS NIH HHS UL1-TR-001079NCRR NIH HHS UL1 RR025005NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS N01-HC-95159NHLBI NIH HHS N01-HC-95160NHLBI NIH HHS N01-HC-95161NHLBI NIH HHS N01-HC-95162NHLBI NIH HHS N01-HC-95163NHLBI NIH HHS N01-HC-95164NHLBI NIH HHS N01-HC-95165NHLBI NIH HHS N01-HC-95166NHLBI NIH HHS N01-HC-95167NHLBI NIH HHS N01-HC-95168NHLBI NIH HHS N01-HC-95169NHLBI NIH HHS R01 HL071739NHLBI NIH HHS R01-HL071739NHLBI NIH HHS R01 HL085323NHLBI NIH HHS R01-HL085323NHLBI NIH HHS R01 HL088451NHLBI NIH HHS R01-HL088451
6 · The paper itself

Abstract

BACKGROUND AND

aimsDietary quality affects cardiometabolic risk, yet its pathways of influence on regional adipose tissue depots involved in metabolic and diabetes risk are not well established. We aimed to investigate the relationship between dietary quality and regional adiposity. METHODS AND

resultsWe investigated 5079 individuals in the Multi-Ethnic Study of Atherosclerosis (MESA) who had food-frequency questionnaires and measurement of pericardial fat and hepatic attenuation at the baseline study visit in MESA, as well as a subgroup with imaging for visceral and subcutaneous fat (N = 1390). A dietary quality score (DietQuality) was constructed to include established food group constituents of a Mediterranean-type diet. Linear models estimated associations of dietary score as well as its constituents with regional adiposity. Baseline mean age was 61 (± 10) years, and approximately half of the participants (47%) were male. Those with a higher DietQuality score were generally older, female, with a lower body mass index, C-reactive protein, and markers of insulin resistance. After adjustment, a higher DietQuality score was associated with lower visceral fat (lowest vs. highest dietary score quartile: 523.6 vs. 460.5 cm(2)/m; P < 0.01 for trend), pericardial fat (47.5 vs. 41.3 cm(3)/m; P < 0.01 for trend), lesser hepatic steatosis (by hepatic attenuation; 58.6 vs. 60.7 Hounsfield units; P < 0.01 for trend), but not subcutaneous fat (P = 0.39). Greater fruits, vegetables, whole grains, seeds/nuts and yogurt intake were associated with decreased adiposity, while red/processed meats were associated with greater regional adiposity.

conclusionA higher quality diet pattern is associated with less regional adiposity, suggesting a potential mechanism of beneficial dietary effects on diabetes, metabolic, and cardiovascular risk.

Indexed as

Body Fat DistributionDiet, HealthyDiet, MediterraneanAgedAtherosclerosisBiomarkersBody Mass IndexBody WeightCholesterol, HDLCholesterol, LDLC-Reactive ProteinCross-Sectional StudiesEthnicityFemaleHumansInsulin ResistanceBiomarkersCholesterol, HDLCholesterol, LDLC-Reactive ProteinTriglyceridesAdiposityBody mass indexDietInflammationObesity

Identifiers

PMID26899879
PMCPMC4788543
OpenAlexW2199158476

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.