ArticleScientific reports2016
Computer-aided multiple-head 3D printing system for printing of heterogeneous organ/tissue constructs.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- Curve-Based Infill Pattern Optimization for 3D Printed Polymeric Scaffolds for Trabecular Bone Applications.Materials (Basel, Switzerland) · 2025Article
- Stimuli-Responsive Self-Healing Ionic Gels: A Promising Approach for Dermal and Tissue Engineering Applications.ACS biomaterials science & engineering · 2025Review
- 3D printing modality effect: Distinct printing outcomes dependent on selective laser sintering (SLS) and melt extrusion.Journal of biomedical materials research. Part A · 2024Article
- Fabrication of fully aligned self-assembled cell-laden collagen filaments for tissue engineeringBioactive materials · 2024Article
- Multilayer 3D bioprinting and complex mechanical properties of alginate-gelatin mesostructures.Scientific reports · 2023Article
- Self-Healing Injectable Hydrogels for Tissue Regeneration.Chemical reviews · 2023Review
- 3D-Printed multi-material liver model with simultaneous mechanical and radiological tissue-mimicking features for improved realism.International journal of bioprinting · 2023Article
- Hybrid biomanufacturing systems applied in tissue regeneration.International journal of bioprinting · 2023Review
- Bioprinting on Organ-on-Chip: Development and Applications.Biosensors · 2022Review
- Techniques, challenges and future prospects for cell-based meat.Food science and biotechnology · 2022Review
- 3D-Printed Electroactive Hydrogel Architectures with Sub-100 µm Resolution Promote Myoblast Viability.Macromolecular bioscience · 2022Article
- A Comprehensive Assessment on the Pivotal Role of Hydrogels in Scaffold-Based Bioprinting.Gels (Basel, Switzerland) · 2022Review
- Optimized 3D Bioprinting Technology Based on Machine Learning: A Review of Recent Trends and Advances.Micromachines · 2022Review
- Stem Cell-Laden Hydrogel-Based 3D Bioprinting for Bone and Cartilage Tissue Engineering.Frontiers in bioengineering and biotechnology · 2022Review
- Accuracy of additive manufacturing in stomatology.Frontiers in bioengineering and biotechnology · 2022Review
- Engineering calcium peroxide based oxygen generating scaffolds for tissue survival.Biomaterials science · 2021Article
- Biofabrication of a shape-stable auricular structure for the reconstruction of ear deformities.Materials today. Bio · 2021Article
- Advances on Bone Substitutes through 3D Bioprinting.International journal of molecular sciences · 2020Review
- Tissue Engineering and Regenerative Medicine: Achievements, Future, and Sustainability in Asia.Frontiers in bioengineering and biotechnology · 2020Review
- Allogenic tooth transplantation using 3D printing: A case report and review of the literature.World journal of clinical cases · 2019Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recently, much attention has focused on replacement or/and enhancement of biological tissues via the use of cell-laden hydrogel scaffolds with an architecture that mimics the tissue matrix, and with the desired three-dimensional (3D) external geometry. However, mimicking the heterogeneous tissues that most organs and tissues are formed of is challenging. Although multiple-head 3D printing systems have been proposed for fabricating heterogeneous cell-laden hydrogel scaffolds, to date only the simple exterior form has been realized. Here we describe a computer-aided design and manufacturing (CAD/CAM) system for this application. We aim to develop an algorithm to enable easy, intuitive design and fabrication of a heterogeneous cell-laden hydrogel scaffolds with a free-form 3D geometry. The printing paths of the scaffold are automatically generated from the 3D CAD model, and the scaffold is then printed by dispensing four materials; i.e., a frame, two kinds of cell-laden hydrogel and a support. We demonstrated printing of heterogeneous tissue models formed of hydrogel scaffolds using this approach, including the outer ear, kidney and tooth tissue. These results indicate that this approach is particularly promising for tissue engineering and 3D printing applications to regenerate heterogeneous organs and tissues with tailored geometries to treat specific defects or injuries.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.