Evidence map›Paper›PMID 26899842›Full record

ArticleBulletin of experimental biology and medicine2016

Efficiency of Umbilical Cord Blood Cells in Patients with Treatment-Resistant Depressions.

A B Smulevich, E B Dubnitskaya, E I Voronova, Ya V Morozova, S M Radaev

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bulletin of experimental biology and medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. The Therapeutic Potential of Stem Cells in Depression.International journal of molecular sciences · 2025
    Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

A B SmulevichResearch Center of Mental Health, Russian Academy of Medical Sciences, Moscow, Russia.
E B DubnitskayaResearch Center of Mental Health, Russian Academy of Medical Sciences, Moscow, Russia.
E I VoronovaResearch Center of Mental Health, Russian Academy of Medical Sciences, Moscow, Russia.
Ya V MorozovaRussian Cardiology Research-and-Production Complex, Ministry of Health of the Russian Federation, Moscow, Russia. yanamorozova0@gmail.com.
S M RadaevCryoCenter Umbilical Cord Blood Bank, Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We studied the efficacy of umbilical cord blood cells in the therapy of treatment-resistant depressive states in women. Concentrated umbilical cord blood cells were administered in a dose of 250 millions cells (4 injections at 1-week intervals). The control group received placebo. In both groups, reduction of depressive disorders and the decrease in hypothymia severity were observed. Infusions of cell concentrate contributed to delayed correction of treatment resistance and reduced the severity of depression to moderate. In the main group, significant, persistent, and long-term positive dynamics was observed in the cognitive sphere. The therapeutic potential of umbilical cord blood cell concentrate can be used to overcome treatment resistance formed in depressive patients.

Indexed as

Hematopoietic Stem Cell TransplantationAdultBipolar and Related DisordersCell- and Tissue-Based TherapyCytokinesDepressive Disorder, Treatment-ResistantFemaleFetal BloodHematopoietic Stem CellsHumansMiddle AgedPlacebosCytokinesPlacebosbipolar affective disordercognitive functionhematopoietic cellsrecurrent depressionumbilical cord blood

Identifiers

PMID26899842
PMCPMC7087609

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.