ArticleNeuroImage2016
Direct neural current imaging in an intact cerebellum with magnetic resonance imaging.
Article in NeuroImage, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 36 citations in OpenAlex.
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- Enhanced magnetic transduction of neuronal activity by nanofabricated inductors quantified via finite element analysis.Journal of neural engineering · 2022Article
- Neuronal current imaging: An experimental method to investigate electrical currents in dogs with idiopathic epilepsy.Journal of veterinary internal medicine · 2021Article
- Boundary Element Fast Multipole Method for Enhanced Modeling of Neurophysiological Recordings.IEEE transactions on bio-medical engineering · 2021Article
- A CMOS NMR needle for probing brain physiology with high spatial and temporal resolution.Nature methods · 2020Article
- Toward direct MRI of neuro-electro-magnetic oscillations in the human brain.Magnetic resonance in medicine · 2019Article
- Magnetic Resonance Imaging technology-bridging the gap between noninvasive human imaging and optical microscopy.Current opinion in neurobiology · 2018Review
- Detection of fast oscillating magnetic fields using dynamic multiple TR imaging and Fourier analysis.PloS one · 2018Article
- Direct detection of neural activity in vitro using magnetic resonance electrical impedance tomography (MREIT).NeuroImage · 2017Article
- Local recording of biological magnetic fields using Giant Magneto Resistance-based micro-probes.Scientific reports · 2016Article
- Optical magnetic detection of single-neuron action potentials using quantum defects in diamond.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
The ability to detect neuronal currents with high spatiotemporal resolution using magnetic resonance imaging (MRI) is important for studying human brain function in both health and disease. While significant progress has been made, we still lack evidence showing that it is possible to measure an MR signal time-locked to neuronal currents with a temporal waveform matching concurrently recorded local field potentials (LFPs). Also lacking is evidence that such MR data can be used to image current distribution in active tissue. Since these two results are lacking even in vitro, we obtained these data in an intact isolated whole cerebellum of turtle during slow neuronal activity mediated by metabotropic glutamate receptors using a gradient-echo EPI sequence (TR=100ms) at 4.7T. Our results show that it is possible (1) to reliably detect an MR phase shift time course matching that of the concurrently measured LFP evoked by stimulation of a cerebellar peduncle, (2) to detect the signal in single voxels of 0.1mm(3), (3) to determine the spatial phase map matching the magnetic field distribution predicted by the LFP map, (4) to estimate the distribution of neuronal current in the active tissue from a group-average phase map, and (5) to provide a quantitatively accurate theoretical account of the measured phase shifts. The peak values of the detected MR phase shifts were 0.27-0.37°, corresponding to local magnetic field changes of 0.67-0.93nT (for TE=26ms). Our work provides an empirical basis for future extensions to in vivo imaging of neuronal currents.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.