ArticleNeuroImage2016
Magnetic susceptibility of brain iron is associated with childhood spatial IQ.
Article in NeuroImage, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.
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Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Brain proton magnetic resonance spectroscopy and neurodevelopment after preterm birth: a systematic review.Pediatric research · 2022Pooled it
- Pooled it
- Metabolomics study of the effects of zinc sulfate in minimal hepatic encephalopathy.Scientific reports · 2026Article
- Beyond anemia: a comprehensive analysis of iron deficiency symptoms in women and their correlation with biomarkers.BMC women's health · 2025Article
- [A single repetition time quantitative magnetic susceptibility imaging method for the lumbar spine using bipolar readout gradient].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2025Article
- Persistent impact of antenatal maternal anaemia on child brain structure at 6-7 years of age: a South African child health study.BMC medicine · 2025Article
- Iron Deficiency and Internalizing Symptoms Among Adolescents in the National Health and Nutrition Examination Survey.Nutrients · 2024Article
- Quantitative susceptibility mapping in the brain reflects spatial expression of genes involved in iron homeostasis and myelination.Human brain mapping · 2024Article
- Persistent Impact of Antenatal Maternal Anaemia on Child Brain Structure at 6-7 Years of Age: A South African Child Health Study.Research square · 2024Article
- Ferroptosis regulation through Nrf2 and implications for neurodegenerative diseases.Archives of toxicology · 2024Review
- Dysregulation of iron homeostasis and ferroptosis in sevoflurane and isoflurane associated perioperative neurocognitive disorders.CNS neuroscience & therapeutics · 2024Review
- Developmental coupling of brain iron and intrinsic activity in infants during the first 150 days.Developmental cognitive neuroscience · 2023Article
- Gestational and postnatal age associations for striatal tissue iron deposition in early infancy.bioRxiv : the preprint server for biology · 2023Article
- Exploring the genetic and genomic connection underlying neurodegeneration with brain iron accumulation and the risk for Parkinson's disease.NPJ Parkinson's disease · 2023Article
- Association of Maternal and Child Anemia With Brain Structure in Early Life in South Africa.JAMA network open · 2022Article
- Ferroptosis promotes microtubule-associated protein tau aggregation via GSK-3β activation and proteasome inhibition.Molecular neurobiology · 2022Article
- Can Nutrients and Dietary Supplements Potentially Improve Cognitive Performance Also in Esports?Healthcare (Basel, Switzerland) · 2022Review
- Sorting Nexin 5 Plays an Important Role in Promoting Ferroptosis in Parkinson's Disease.Oxidative medicine and cellular longevity · 2022Article
- Serum micronutrient status, sleep quality and neurobehavioural function among early adolescents.Public health nutrition · 2021Article
- R2* and quantitative susceptibility mapping in deep gray matter of 498 healthy controls from 5 to 90 years.Human brain mapping · 2021Article
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Authors and funding
8 authors.
Funding
Abstract
Iron is an essential micronutrient for healthy brain function and development. Because of the importance of iron in the brain, iron deficiency results in widespread and lasting effects on behavior and cognition. We measured iron in the basal ganglia of young children using a novel MRI method, quantitative susceptibility mapping, and examined the association of brain iron with age and cognitive performance. Participants were a community sample of 39 young children recruited from pediatric primary care who were participating in a 5-year longitudinal study of child brain development and anxiety disorders. The children were ages 7 to 11years old (mean age: 9.5years old) at the time of the quantitative susceptibility mapping scan. The differential abilities scale was administered when the children were 6years old to provide a measure of general intelligence and verbal (receptive and expressive), non-verbal, and spatial performance. Magnetic susceptibility values, which are linearly related to iron concentration in iron-rich areas, were extracted from regions of interest within iron-rich deep gray matter nuclei from the basal ganglia, including the caudate, putamen, substantia nigra, globus pallidus, and thalamus. Controlling for scan age, there was a significant positive association between iron in the basal ganglia and spatial IQ, with this effect being driven by iron in the right caudate We also replicated previous findings of a significant positive association between iron in the bilateral basal ganglia and age. Our finding of a positive association between spatial IQ and mean iron in the basal ganglia, and in the caudate specifically, suggests that iron content in specific regions of the iron-rich deep nuclei of the basal ganglia influences spatial intelligence. This provides a potential neurobiological mechanism linking deficits in spatial abilities reported in children who were severely iron deficient as infants to decreased iron within the caudate.
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