ArticlePsychological medicine2016
Multidimensional assessment of impulsivity in schizophrenia, bipolar disorder, and major depressive disorder: testing for shared endophenotypes.
Article in Psychological medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 53 citations in OpenAlex.
- Metabotropic glutamate receptor 5 in the anterior cingulate cortex predicts individual differences in motor impulsivity but not in risky decision-making.Translational psychiatry · 2026Article
- The potential of event-related beta oscillations as biomarkers for neuromodulatory treatment efficacy.Frontiers in psychology · 2026Article
- Characterizing the Pleiotropic Architecture of Impulsivity and Its Links to Psychopathology and Neurodevelopment.The American journal of psychiatry · 2026Article
- Exploring Gender Differences in the Relationship Between Thyroid Function and Aggressive and Impulsive Behaviors in Patients with Major Depressive Disorder.Neuropsychiatric disease and treatment · 2025Article
- Distinct Effects of Major Affective Disorder Diagnoses and Suicidal Symptom Severity on Inhibitory Control Function and Proinflammatory Cytokines: Single-Site Analysis of 800 Adolescents and Adults.The international journal of neuropsychopharmacology · 2024Article
- Characterizing clinical heterogeneity in an inpatient service treating mental, substance use and concurrent disorders.PLOS mental health · 2024Article
- Neural signature of error processing in major depression.European archives of psychiatry and clinical neuroscience · 2021Article
- Altered Effective Connectivity within an Oculomotor Control Network in Unaffected Relatives of Individuals with Schizophrenia.Brain sciences · 2021Article
- Accelerated brain aging predicts impulsivity and symptom severity in depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- How Do Critical Thinking Ability and Critical Thinking Disposition Relate to the Mental Health of University Students?Frontiers in psychology · 2021Article
- Distinguishing patterns of impairment on inhibitory control and general cognitive ability among bipolar with and without psychosis, schizophrenia, and schizoaffective disorder.Schizophrenia research · 2020Article
- Impaired automatic but intact volitional inhibition in primary tic disorders.Brain : a journal of neurology · 2020Article
- Delay discounting abnormalities are seen in first-episode schizophrenia but not in bipolar disorder.Schizophrenia research · 2020Article
- Abnormal neural functions associated with motor inhibition deficits in schizophrenia and bipolar disorder.Human brain mapping · 2019Article
- Cross-diagnostic analysis of cognitive control in mental illness: Insights from the CNTRACS consortium.Schizophrenia research · 2019Article
- The schizophrenia and bipolar twin study in Sweden (STAR).Schizophrenia research · 2019Article
- Attention Problems Predict Risk of Violence and Rehabilitative Engagement in Mentally Disordered Offenders.Frontiers in psychiatry · 2019Article
- Problem and Pathological Gambling in Schizophrenia: Exploring Links with Substance Use and Impulsivity.Journal of gambling studies · 2018Article
- Reduced pupil dilation during action preparation in schizophrenia.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2018Article
- Impulsivity in unaffected adolescent biological relatives of schizophrenia patients.Journal of psychiatric research · 2018Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundImpulsivity is associated with bipolar disorder as a clinical feature during and between manic episodes and is considered a potential endophenotype for the disorder. Schizophrenia and major depressive disorder share substantial genetic overlap with bipolar disorder, and these two disorders have also been associated with elevations in impulsivity. However, little is known about the degree of overlap among these disorders in discrete subfacets of impulsivity and whether any overlap is purely phenotypic or due to shared genetic diathesis.
methodWe focused on five subfacets of impulsivity: self-reported attentional, motor, and non-planning impulsivity, self-reported sensation seeking, and a behavioral measure of motor inhibition (stop signal reaction time; SSRT). We examined these facets within and across disorder proband and co-twin groups, modeled heritability, and tested for endophenotypic patterning in a sample of twin pairs recruited from the Swedish Twin Registry (N = 420).
resultsWe found evidence of moderate to high levels of heritability for all five subfacets. All three proband groups and their unaffected co-twins showed elevations on attentional, motor, and non-planning impulsivity. Schizophrenia probands (but not their co-twins) showed significantly lower sensation seeking, and schizophrenia and bipolar disorder probands (but not in their co-twins) had significantly longer SSRTs, compared with healthy controls and the other groups.
conclusionsAttentional, motor, and non-planning impulsivity emerged as potential shared endophenotypes for the three disorders, whereas sensation seeking and SSRT were associated with phenotypic affection but not genetic loading for these disorders.
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