ArticleAge (Dordrecht, Netherlands)2016
Intramuscular fat and physical performance at the Framingham Heart Study.
Article in Age (Dordrecht, Netherlands), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effects of exercise with or without a hypocaloric diet on intermuscular and intramuscular fat: a systematic review.Aging clinical and experimental research · 2025Pooled it
- Effect of liraglutide on thigh muscle fat and muscle composition in adults with overweight or obesity: Results from a randomized clinical trial.Journal of cachexia, sarcopenia and muscle · 2024 · on this mapTrial
- Effect of Protein Supplementation During Diet-Induced Weight Loss on Muscle Mass and Strength: A Randomized Controlled Study.Obesity (Silver Spring, Md.) · 2018Trial
- Article
- Association of habitual diet with skeletal muscle composition in a cross-sectional, population-based imaging study.Nutrition journal · 2025Article
- Administration of heat killed Fructobacillus fructosus OS-1010 attenuates metabolic disease induced by high fat diet in mice.Scientific reports · 2025Article
- Article
- Review
- Impact of Adipose Tissue and Lipids on Skeletal Muscle in Sarcopenia.Journal of cachexia, sarcopenia and muscle · 2025Review
- The Etiology of Reduced Muscle Mass with Surgical and Pharmacological Weight Loss and the Identification of Potential Countermeasures.Nutrients · 2024Review
- Skeletal muscle mass and quality in gout patients versus non-gout controls: A computed tomography imaging study.Joint bone spine · 2024Article
- A multifaceted and inclusive methodology for the detection of sarcopenia in patients undergoing bariatric surgery: an in-depth analysis of current evidence.Reviews in endocrine & metabolic disorders · 2024Review
- Fibro-adipogenic progenitors in physiological adipogenesis and intermuscular adipose tissue remodeling.Molecular aspects of medicine · 2024Review
- NAFLD Associates with Sarcopenia Defined by Muscle Mass and Slow Walking Speed: A Cross-Sectional Analysis from the Framingham Heart Study.Journal of clinical medicine · 2023Article
- Thigh and Calf Myosteatosis are Strongly Associated with Muscle and Physical Function in African Caribbean Men.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Sex differences in frailty of geriatric outpatients with type 2 diabetes mellitus: a multicentre cross-sectional study.Scientific reports · 2022Article
- Associations between physical fitness components with muscle ultrasound parameters in prepuberal children.International journal of obesity (2005) · 2022Article
- The psoas muscle density as a predictor of postoperative complications and 30-day mortality for acute mesenteric ischemia patients.Abdominal radiology (New York) · 2022Article
- Physical Activity Type and Intensity Are Associated With Abdominal Muscle Area and Density: The Multiethnic Study of Atherosclerosis.Journal of physical activity & health · 2022Article
- Computed tomography-based skeletal muscle and adipose tissue attenuation: Variations by age, sex, and muscle.Experimental gerontology · 2021Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Intramuscular fat may mediate associations between obesity and physical disability. We examined the associations between muscle attenuation, a proxy for intramuscular fat, and physical function. Paraspinous muscle computed tomography attenuation was obtained on a Framingham Heart Study subgroup (n = 1152, 56 % women, mean age 66 years). Regressions modeled cross-sectional associations between muscle attenuation and mobility disability, grip strength, and walking speed with standard covariates; models additionally adjusted for body mass index (BMI) and visceral adipose tissue (VAT). Separate models investigated associations between VAT and subcutaneous adipose tissue (SAT) and physical function. Per 1 standard deviation decrement in muscle attenuation (i.e., more muscle fat), we observed 1.29 (95 % CI = 1.11, 1.50; p = 0.0009) increased odds of walking speed ≤1 m/s in women and men. This persisted after separate BMI and VAT adjustments (p < 0.02). In men, there was a 1.29 kg (95 % CI = 0.57, 2.01; p = 0.0005) decrement in grip strength, which persisted after BMI and VAT adjustments (p ≤ 0.0004). For VAT and SAT, similar associations were not observed. Intramuscular fat is associated with increased odds of walking speed ≤1 m/s in both sexes and lower grip strength in men. There were no similar associations for VAT and SAT, highlighting the specificity of intramuscular fat in association with physical function.
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