Evidence map›Paper›PMID 26898779›Full record

ArticleNeuron2016

A Systems-Level Analysis of the Peripheral Nerve Intrinsic Axonal Growth Program.

Vijayendran Chandran, Giovanni Coppola, Homaira Nawabi, Takao Omura, Revital Versano, Eric A Huebner, Alice Zhang, Michael Costigan, Ajay Yekkirala, Lee Barrett and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuron, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 216 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
216citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

216 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  11. Deletion of murineScience translational medicine · 2025
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  20. The peripheral Atf3Acta biochimica et biophysica Sinica · 2025
    Article

156 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors.

Vijayendran ChandranProgram in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Giovanni CoppolaProgram in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Psychiatry, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.
Homaira NawabiF.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Takao OmuraF.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Revital VersanoProgram in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Eric A HuebnerF.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Alice ZhangInterdepartmental Program in Neuroscience, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Michael CostiganF.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Ajay YekkiralaF.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Lee BarrettF.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Armin BleschDepartment of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA.
Izhak MichaelevskiDepartment of Biological Chemistry, Weizmann Institute of Science, 76100 Rehovot, Israel.
Jeremy Davis-TurakProgram in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Fuying GaoDepartment of Psychiatry, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.
Peter LangfelderDepartment of Human Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Biostatistics, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Steve HorvathDepartment of Human Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Biostatistics, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Zhigang HeF.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Larry BenowitzF.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Mike FainzilberDepartment of Biological Chemistry, Weizmann Institute of Science, 76100 Rehovot, Israel.
Mark TuszynskiDepartment of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA.
Clifford J WoolfF.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Daniel H GeschwindProgram in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Human Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: dhg@mednet.ucla.edu.

Funding

ALTERED SENSIBILITY FOLLOWING PERIPHERAL NERVE DAMAGER01NS038253 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI WOOLF, CLIFFORD J · 1999 to 2017
$8.2M
Integrative Center for Neurogenetics and Neurogenomics - OverallP30NS062691 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI COPPOLA, GIOVANNI, FREIMER, NELSON B. · 2009 to 2018
$7.4M
Mouse Neurodevelopmental Behavior CoreU54HD090255 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI POMEROY, SCOTT LOREN · 2016 to 2020
$5.2M
The mechanisms of action of T-lymphocytes in neuropathic painR01NS074430 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI COSTIGAN, MICHAEL · 2012 to 2016
$2.0M
NICHD NIH HHS U54 HD090255NINDS NIH HHS NS074430NINDS NIH HHS P30 NS062691NINDS NIH HHS R01 NS038253NINDS NIH HHS R01 NS074430
6 · The paper itself

Abstract

The regenerative capacity of the injured CNS in adult mammals is severely limited, yet axons in the peripheral nervous system (PNS) regrow, albeit to a limited extent, after injury. We reasoned that coordinate regulation of gene expression in injured neurons involving multiple pathways was central to PNS regenerative capacity. To provide a framework for revealing pathways involved in PNS axon regrowth after injury, we applied a comprehensive systems biology approach, starting with gene expression profiling of dorsal root ganglia (DRGs) combined with multi-level bioinformatic analyses and experimental validation of network predictions. We used this rubric to identify a drug that accelerates DRG neurite outgrowth in vitro and optic nerve outgrowth in vivo by inducing elements of the identified network. The work provides a functional genomics foundation for understanding neural repair and proof of the power of such approaches in tackling complex problems in nervous system biology.

Indexed as

AnimalsAnimals, NewbornAntigens, NeoplasmAxonscdc42 GTP-Binding ProteinCell Adhesion MoleculesCells, CulturedChromatin ImmunoprecipitationDisease Models, AnimalGanglia, SpinalGene Expression RegulationGlutamine-Fructose-6-Phosphate Transaminase (Isomerizing)Ion ChannelsMembrane GlycoproteinsMembrane ProteinsMiceAntigens, Neoplasmcdc42 GTP-Binding ProteinCell Adhesion MoleculesFXYD5 protein, mouseGfpt1 protein, mouseGlutamine-Fructose-6-Phosphate Transaminase (Isomerizing)Ion ChannelsMembrane GlycoproteinsMembrane ProteinsMicrofilament ProteinsNitrogenous Group TransferasesPTEN PhosphohydrolaseTROP2 protein, mouse

Identifiers

PMID26898779
PMCPMC4790095

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.