ArticleNeuron2016
Cross-Modality Sharpening of Visual Cortical Processing through Layer-1-Mediated Inhibition and Disinhibition.
Article in Neuron, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 160 papers.
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Who cites it
160 citing papers in PubMed, 330 citations in OpenAlex.
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- Sensory origin of visually evoked activity in auditory cortex.Cell reports · 2025Article
- Biologically grounded neocortex computational primitives implemented on neuromorphic hardware improve vision transformer performance.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Seeing what you hear: Compression of rat visual perceptual space by task-irrelevant sounds.PLoS computational biology · 2025Article
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- Auditory cortex learns to discriminate audiovisual cues through selective multisensory enhancement.eLife · 2025Article
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- Neural processing of naturalistic audiovisual events in space and time.Communications biology · 2025Article
- Discretized representations in V1 predict suboptimal orientation discrimination.Nature communications · 2025Article
- Multisensory integration, brain plasticity and optogenetics in visual rehabilitation.Frontiers in neurology · 2025Review
- Circuit-level modeling of prediction error computation of multi-dimensional features in voluntary actions.Frontiers in computational neuroscience · 2025Article
- A comparative view of human and mouse telencephalon inhibitory neuron development.Development (Cambridge, England) · 2025Review
- Auditory sensory processing induces cortical and thalamic event-related desynchronization in the mouse.PloS one · 2025Article
100 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Cross-modality interaction in sensory perception is advantageous for animals' survival. How cortical sensory processing is cross-modally modulated and what are the underlying neural circuits remain poorly understood. In mouse primary visual cortex (V1), we discovered that orientation selectivity of layer (L)2/3, but not L4, excitatory neurons was sharpened in the presence of sound or optogenetic activation of projections from primary auditory cortex (A1) to V1. The effect was manifested by decreased average visual responses yet increased responses at the preferred orientation. It was more pronounced at lower visual contrast and was diminished by suppressing L1 activity. L1 neurons were strongly innervated by A1-V1 axons and excited by sound, while visual responses of L2/L3 vasoactive intestinal peptide (VIP) neurons were suppressed by sound, both preferentially at the cell's preferred orientation. These results suggest that the cross-modality modulation is achieved primarily through L1 neuron- and L2/L3 VIP-cell-mediated inhibitory and disinhibitory circuits.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.