Evidence map›Paper›PMID 26898714›Full record

ArticleTranslational research : the journal of laboratory and clinical medicine2016

Allergic lung inflammation promotes atherosclerosis in apolipoprotein E-deficient mice.

Cong-Lin Liu, Yi Wang, Mengyang Liao, Marcela M Santos, Cleverson Fernandes, Galina K Sukhova, Jin-Ying Zhang, Xiang Cheng, Chongzhe Yang, Xiaozhu Huang and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational research : the journal of laboratory and clinical medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 19 citations in OpenAlex.

  1. Observational
  2. Apolipoprotein E promoted the proliferation and function of group 2 innate lymphoid cells through low density lipoprotein receptor in allergic rhinitis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025
    Article
  3. Review
  4. Review
  5. Review
  6. Observational
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 2 countries.

Cong-Lin LiuDepartment of Cardiology, Institute of Clinical Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass, USA.
Yi WangDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass, USA; Department of Cardiology, Shanghai First People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Mengyang LiaoDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass, USA; Institute of Cardiology, Union Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.
Marcela M SantosDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass, USA.
Cleverson FernandesDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass, USA.
Galina K SukhovaDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass, USA.
Jin-Ying ZhangDepartment of Cardiology, Institute of Clinical Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Xiang ChengInstitute of Cardiology, Union Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.
Chongzhe YangDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass, USA; Department of Geriatrics, National Key Clinical Specialty, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, China.
Xiaozhu HuangDepartment of Medicine, University of California, San Francisco, Calif, USA.
Bruce LevyDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass, USA.
Peter LibbyDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass, USA.
Gongxiong WuResearch Division, Joslin Diabetes Center, Harvard Medical School, Boston, Mass, USA; Department of Cardiovascular, The Second Hospital Affiliated to Guangzhou Medical University, Guangzhou Institute of Cardiovascular Disease, Guangzhou 510182, Guangdong Province, China. Electronic address: gongxiong.wu@joslin.harvard.edu.
Guo-Ping ShiDepartment of Cardiology, Institute of Clinical Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass, USA. Electronic address: gshi@bwh.harvard.edu.
Brigham and Women's Hospital · USHarvard University · USFirst Affiliated Hospital of Zhengzhou University · CNHuazhong University of Science and Technology · CNJoslin Diabetes Center · USShanghai Jiao Tong University · CNUniversity of California, San Francisco · US

Funding

Tissue AnalysesP01HL048743 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI GLADYSHEV, VADIM N. · 1992 to 2014
$26.3M
Role of mast cells in obesityR01HL060942 · NHLBI · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI SHI, GUO-PING · 1999 to 2019
$5.6M
Molecular Determinants of Arterial Remodeling in AtherogenesisR01HL080472 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LIBBY, PETER · 2005 to 2018
$5.0M
Role of Mast Cells in AtherosclerosisR01HL081090 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SHI, GUO-PING · 2007 to 2015
$3.3M
Role of a novel IL18 binding protein in atherosclerosisR01HL123568 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SHI, GUO-PING · 2015 to 2018
$1.7M
NHLBI NIH HHS HL080472NHLBI NIH HHS HL123568NHLBI NIH HHS HL48743NHLBI NIH HHS HL60942NHLBI NIH HHS HL81090NHLBI NIH HHS P01 HL048743NHLBI NIH HHS R01 HL060942NHLBI NIH HHS R01 HL080472NHLBI NIH HHS R01 HL081090NHLBI NIH HHS R01 HL123568
6 · The paper itself

Abstract

Inflammation drives asthma and atherosclerosis. Clinical studies suggest that asthmatic patients have a high risk of atherosclerosis. Yet this hypothesis remains uncertain, given that Th2 imbalance causes asthma whereas Th1 immunity promotes atherosclerosis. In this study, chronic allergic lung inflammation (ALI) was induced in mice by ovalbumin sensitization and challenge. Acute ALI was induced in mice by ovalbumin and aluminum sensitization and ovalbumin challenge. Atherosclerosis was produced in apolipoprotein E-deficient (Apoe(-/-)) mice with a Western diet. When chronic ALI and atherosclerosis were produced simultaneously, ALI increased atherosclerotic lesion size, lesion inflammatory cell content, elastin fragmentation, smooth muscle cell (SMC) loss, lesion cell proliferation, and apoptosis. Production of acute ALI before atherogenesis did not affect lesion size, but increased atherosclerotic lesion CD4(+) T cells, lesion SMC loss, angiogenesis, and apoptosis. Production of acute ALI after atherogenesis also did not change atherosclerotic lesion area, but increased lesion elastin fragmentation, cell proliferation, and apoptosis. In mice with chronic ALI and diet-induced atherosclerosis, daily inhalation of a mast cell inhibitor or corticosteroid significantly reduced atherosclerotic lesion T-cell and mast cell contents, SMC loss, angiogenesis, and cell proliferation and apoptosis, although these drugs did not affect lesion area, compared with those that received vehicle treatment. In conclusion, both chronic and acute ALI promote atherogenesis or aortic lesion pathology, regardless whether ALI occurred before, after, or at the same time as atherogenesis. Antiasthmatic medication can efficiently mitigate atherosclerotic lesion pathology.

Indexed as

AnimalsApolipoproteins EAtherosclerosisBudesonideChronic DiseaseDisease ProgressionGlucocorticoidsHypersensitivityInflammationKetotifenMaleMast CellsMice, Inbred C57BLMice, KnockoutOvalbuminPneumoniaApolipoproteins EBudesonideGlucocorticoidsKetotifenOvalbumin

Identifiers

PMID26898714
PMCPMC4833597
OpenAlexW2258752792

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.