Evidence map›Paper›PMID 26898682›Full record

ArticleJournal of pediatric surgery2017

Outcomes of minimally invasive parathyroidectomy in pediatric patients with primary hyperparathyroidism owing to parathyroid adenoma: A single institution experience.

Edna E Mancilla, Michael A Levine, N Scott Adzick

Open access · greenAbstract read
In one paragraph

Article in Journal of pediatric surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Edna E MancillaDivision of Endocrinology and Diabetes, The Children's Hospital of Philadelphia, and the University of Pennsylvania Perelman School of Medicine.
Michael A LevineDivision of Endocrinology and Diabetes, The Children's Hospital of Philadelphia, and the University of Pennsylvania Perelman School of Medicine. Electronic address: levinem@chop.edu.
N Scott AdzickDepartment of Surgery, The Children's Hospital of Philadelphia, and the University of Pennsylvania Perelman School of Medicine.
Children's Hospital of Philadelphia · US

Funding

The Role of GCM2 in Parathyroid Gland HomeostasisR01DK079970 · NIDDK · CHILDREN'S HOSP OF PHILADELPHIA · PI LEVINE, MICHAEL A. · 2009 to 2015
$3.2M
NIDDK NIH HHS R01 DK079970
6 · The paper itself

Abstract

backgroundGuidelines for treatment of primary hyperparathyroidism (PHPT) in young patients recommend surgery. Outcomes of minimally invasive parathyroidectomy (MIP) are well established in adults, but not in pediatric patients.

objectiveThe objective of the study is to determine effectiveness of preoperative imaging and MIP aided by intraoperative PTH (ioPTH) measurement in children with primary hyperparathyroidism (PHPT). METHODS AND

designThis is a retrospective chart review of diagnostic and follow-up data up to 12months post-MIP of patients with PHPT who underwent parathyroidectomy at the Children's Hospital of Philadelphia between January 1, 2009 and March 31, 2015.

resultsData were available for 16 of 17 patients age 8-17years (11 females, 6 males): 2 had ectopic intrathymic adenomas while 14 had eutopic adenomas. Fifteen patients had ioPTH, including 14 who underwent MIP, defined as a 2cm central neck incision. All patients with data at 6months postparathyroidectomy (13/16) showed normal PTH and calcium. Ultrasound and sestamibi scans had a combined sensitivity of 87.5%.

conclusionsMIP is an appropriate alternative to standard neck exploration in pediatric patients with PHPT with a single parathyroid adenoma. ioPTH is especially useful to confirm cure and limit surgical exploration when imaging studies are negative. Sestamibi scans and ultrasound are complementary studies.

Indexed as

AdenomaAdolescentChildFemaleHumansHyperparathyroidism, PrimaryMaleMinimally Invasive Surgical ProceduresParathyroidectomyParathyroid NeoplasmsRetrospective StudiesTomography, Emission-Computed, Single-PhotonTreatment OutcomeUltrasonographyHypercalcemiaHyperparathyroidismIntraoperative PTHMinimally invasive parathyroidectomy

Identifiers

PMID26898682
PMCPMC4974154
OpenAlexW2265690776

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.