Evidence map›Paper›PMID 26898644›Full record

ArticleJournal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry2016

Spectroscopic and biological activity studies of the chromium-binding peptide EEEEGDD.

Hirohumi Arakawa, Machender R Kandadi, Evgeniy Panzhinskiy, Kenneth Belmore, Ge Deng, Ebony Love, Preshus M Robertson, Juliette J Commodore, Carolyn J Cassady, Sreejayan Nair and 1 more

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Article in Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Hirohumi ArakawaDepartment of Chemistry, The University of Alabama, Tuscaloosa, AL, 35487-0336, USA.
Machender R KandadiCenter for Cardiovascular Research and Alternative Medicine, School of Pharmacy, University of Wyoming, Laramie, WY, 82071, USA.
Evgeniy PanzhinskiyCenter for Cardiovascular Research and Alternative Medicine, School of Pharmacy, University of Wyoming, Laramie, WY, 82071, USA.
Kenneth BelmoreDepartment of Chemistry, The University of Alabama, Tuscaloosa, AL, 35487-0336, USA.
Ge DengDepartment of Chemistry, The University of Alabama, Tuscaloosa, AL, 35487-0336, USA.
Ebony LoveDepartment of Chemistry, The University of Alabama, Tuscaloosa, AL, 35487-0336, USA.
Preshus M RobertsonDepartment of Chemistry, The University of Alabama, Tuscaloosa, AL, 35487-0336, USA.
Juliette J CommodoreDepartment of Chemistry, The University of Alabama, Tuscaloosa, AL, 35487-0336, USA.
Carolyn J CassadyDepartment of Chemistry, The University of Alabama, Tuscaloosa, AL, 35487-0336, USA.
Sreejayan NairCenter for Cardiovascular Research and Alternative Medicine, School of Pharmacy, University of Wyoming, Laramie, WY, 82071, USA.
John B VincentDepartment of Chemistry, The University of Alabama, Tuscaloosa, AL, 35487-0336, USA. jvincent@bama.ua.edu.
University of Alabama · USUniversity of Wyoming · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While trivalent chromium has been shown at high doses to have pharmacological effects improving insulin resistance in rodent models of insulin resistance, the mechanism of action of chromium at a molecular level is not known. The chromium-binding and transport agent low-molecular-weight chromium-binding substance (LMWCr) has been proposed to be the biologically active form of chromium. LMWCr has recently been shown to be comprised of a heptapeptide of the sequence EEEEDGG. The binding of Cr(3+) to this heptapeptide has been examined. Mass spectrometric and a variety of spectroscopic studies have shown that multiple chromic ions bind to the peptide in an octahedral fashion through carboxylate groups and potentially small anionic ligands such as oxide and hydroxide. A complex of Cr and the peptide when administered intravenously to mice is able to decrease area under the curve in intravenous glucose tolerance tests. It can also restore insulin-stimulated glucose uptake in myotubes rendered insulin resistant by treating them with a high-glucose media.

Indexed as

AnimalsCells, CulturedChromiumGlucoseGlucose Tolerance TestInjections, IntravenousInsulin ResistanceMagnetic Resonance SpectroscopyMaleMiceMice, Inbred StrainsOligopeptidesSpectrometry, FluorescenceSpectrophotometry, InfraredChromiumGlucoseOligopeptidesChromiumGlucose tolerance testMyotubesPeptideSpectroscopy

Identifiers

PMID26898644
OpenAlexW2281849545

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.