ArticleScientific reports2016
Heterogeneity induces rhythms of weakly coupled circadian neurons.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 24 citations in OpenAlex.
- A minimal model of peripheral clocks reveals differential circadian re-entrainment in aging.Chaos (Woodbury, N.Y.) · 2023Article
- Review
- Heritable gene expression variability and stochasticity govern clonal heterogeneity in circadian period.PLoS biology · 2020Article
- Noise-driven cellular heterogeneity in circadian periodicity.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Globally fixed-time synchronization of coupled neutral-type neural network with mixed time-varying delays.PloS one · 2018Article
- Plasticity in the Period of the Circadian Pacemaker Induced by Phase Dispersion of Its Constituent Cellular Clocks.Journal of biological rhythms · 2017Article
- Synchronization in slowly switching networks of coupled oscillators.Scientific reports · 2016Article
- The synchronization of neuronal oscillators determined by the directed network structure of the suprachiasmatic nucleus under different photoperiods.Scientific reports · 2016Article
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Authors and funding
4 authors at 3 institutions in 2 countries.
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Abstract
The main clock located in the suprachiasmatic nucleus (SCN) regulates circadian rhythms in mammals. The SCN is composed of approximately twenty thousand heterogeneous self-oscillating neurons, that have intrinsic periods varying from 22 h to 28 h. They are coupled through neurotransmitters and neuropeptides to form a network and output a uniform periodic rhythm. Previous studies found that the heterogeneity of the neurons leads to attenuation of the circadian rhythm with strong cellular coupling. In the present study, we investigate the heterogeneity of the neurons and of the network in the condition of constant darkness. Interestingly, we found that the heterogeneity of weakly coupled neurons enables them to oscillate and strengthen the circadian rhythm. In addition, we found that the period of the SCN network increases with the increase of the degree of heterogeneity. As the network heterogeneity does not change the dynamics of the rhythm, our study shows that the heterogeneity of the neurons is vitally important for rhythm generation in weakly coupled systems, such as the SCN, and it provides a new method to strengthen the circadian rhythm, as well as an alternative explanation for differences in free running periods between species in the absence of the daily cycle.
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