ArticleNature communications2016
Rapid and continuous activity-dependent plasticity of olfactory sensory input.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- Immature olfactory sensory neurons provide complementary input in the intact olfactory system.iScience · 2026Article
- Olfactory epithelium regeneration and homeostasis: cellular and molecular mechanisms and novel methodological advances.Cell regeneration (London, England) · 2026Review
- Non-uniform endogenous regeneration of olfactory sensory neuron axons across the mouse olfactory bulb.Scientific reports · 2026Article
- Immature olfactory sensory neurons are intrinsically excitable and show maturation-dependent changes in voltage-gated NaPflugers Archiv : European journal of physiology · 2026Article
- New Neurons in the Postnatal Olfactory System: Functions in the Healthy and Regenerating Brain.Brain sciences · 2025Review
- Integrating optogenetic stimulation of olfactory bulb glomeruli with foot shock fear conditioning: A robust method for investigating olfactory-based fear conditioning.The European journal of neuroscience · 2025Article
- Cell type- and layer-specific plasticity of olfactory bulb interneurons following olfactory sensory neuron ablation.Scientific reports · 2024Article
- The influence of olfactory experience on the birthrates of olfactory sensory neurons with specific odorant receptor identities.Genesis (New York, N.Y. : 2000) · 2024Review
- Deprivation-Induced Plasticity in the Early Central Circuits of the Rodent Visual, Auditory, and Olfactory Systems.eNeuro · 2024Review
- Activity-dependent formation of the topographic map and the critical period in the development of mammalian olfactory system.Genesis (New York, N.Y. : 2000) · 2024Review
- Post-exposure intranasal IFNα suppresses replication and neuroinvasion of Venezuelan Equine Encephalitis virus within olfactory sensory neurons.Journal of neuroinflammation · 2024Article
- The role of a ciliary GTPase in the regulation of neuronal maturation of olfactory sensory neurons.Development (Cambridge, England) · 2023Article
- Identification and Localization of Cell Types in the Mouse Olfactory Bulb Using Slide-SeqV2.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Immature olfactory sensory neurons provide behaviourally relevant sensory input to the olfactory bulb.Nature communications · 2022Article
- Brief sensory deprivation triggers plasticity of dopamine-synthesising enzyme expression in genetically labelled olfactory bulb dopaminergic neurons.The European journal of neuroscience · 2022Article
- Developing and maintaining a nose-to-brain map of odorant identity.Open biology · 2022Review
- The Entorhinal Cortical Alvear Pathway Differentially Excites Pyramidal Cells and Interneuron Subtypes in Hippocampal CA1.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Brief Sensory Deprivation Triggers Cell Type-Specific Structural and Functional Plasticity in Olfactory Bulb Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Open Frontiers in Neural Cell Type Investigations; Lessons FromFrontiers in neuroscience · 2021Review
- The influence of stimulus duration on olfactory perception.PloS one · 2021Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Incorporation of new neurons enables plasticity and repair of circuits in the adult brain. Adult neurogenesis is a key feature of the mammalian olfactory system, with new olfactory sensory neurons (OSNs) wiring into highly organized olfactory bulb (OB) circuits throughout life. However, neither when new postnatally generated OSNs first form synapses nor whether OSNs retain the capacity for synaptogenesis once mature, is known. Therefore, how integration of adult-born OSNs may contribute to lifelong OB plasticity is unclear. Here, we use a combination of electron microscopy, optogenetic activation and in vivo time-lapse imaging to show that newly generated OSNs form highly dynamic synapses and are capable of eliciting robust stimulus-locked firing of neurons in the mouse OB. Furthermore, we demonstrate that mature OSN axons undergo continuous activity-dependent synaptic remodelling that persists into adulthood. OSN synaptogenesis, therefore, provides a sustained potential for OB plasticity and repair that is much faster than OSN replacement alone.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.