ArticleCell2016
Sialylated Milk Oligosaccharides Promote Microbiota-Dependent Growth in Models of Infant Undernutrition.
Article in Cell, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05629624 (Multidimensional Evaluation of the Early Emergence of Executive Function and Emotional Regulation in Young Children in Bangladesh Using Nutritional and Psychosocial Intervention), which is not on this map. Cited by 302 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Multidimensional Evaluation of the Early Emergence of Executive Function and Emotional Regulation in Young Children in Bangladesh Using Nutritional and Psychosocial Intervention: A Pilot Study
Who cites it
302 citing papers in PubMed, 619 citations in OpenAlex.
- Association of human milk oligosaccharides and nutritional status of young infants among Bangladeshi mother-infant dyads.Scientific reports · 2022Trial
- Fecal metatranscriptomics and glycomics suggest that bovine milk oligosaccharides are fully utilized by healthy adults.The Journal of nutritional biochemistry · 2020Trial
- Response of the Human Milk Microbiota to A Maternal Prebiotic Intervention is Individual and Influenced by Maternal Age.Nutrients · 2020Trial
- The effect of legume supplementation on the gut microbiota in rural Malawian infants aged 6 to 12 months.The American journal of clinical nutrition · 2020Trial
- Maternal Human Milk Oligosaccharide Profile Modulates the Impact of an Intervention with Iron and Galacto-Oligosaccharides in Kenyan Infants.Nutrients · 2019Trial
- Effects of microbiota-directed foods in gnotobiotic animals and undernourished children.Science (New York, N.Y.) · 2019Trial
- Glycosylation in gut-brain communication: from the intestinal barrier and microbiota to immune and neural signaling.Gut microbes · 2026Review
- Effects of Compound Milk Oligosaccharides on Growth Performance, Immune Function, and Intestinal Health of Neonatal Suckling Piglets with Different Birth Weights.Animals : an open access journal from MDPI · 2026Article
- Early-Life Compound Probiotic Intervention Programs Intestinal Barrier Maturation Through Indole-3-Lactic Acid in a Porcine Model.Nutrients · 2026Article
- Hyaluronic Acid-Based Injectable Dual-Network Hydrogel for 6'-Sialyllactose Mimetic Peptide Delivery and Microenvironment Reconstruction in Brachial Plexus Root Avulsion.Advanced healthcare materials · 2026Article
- Maternal and infant gut microbiome.iMeta · 2026Review
- Varied human milk oligosaccharides in human milk from mothers treated with antidepressants and anti-inflammatories.Pediatric research · 2026Article
- Comparative Analysis of Bovine Fecal Microbiota and Short-Chain Fatty Acids Variation During Dry Period, Pregnancy and Lactation.Microorganisms · 2026Article
- Human milk oligosaccharide mediates mutualism between Escherichia coli and Bifidobacterium bifidum.Nature communications · 2026Article
- Untargeted Metabolomics Analysis of Human Milk from Breastfeeding Bangladeshi Women Reveals Amino Acid Metabolic Pathways Associated with Maternal Nutritional Status and Infant Growth.The Journal of nutrition · 2026Article
- Effect of a Synbiotic Combination of 2'-Fucosyllactose andNutrients · 2026Article
- Effects of N-Acetylneuraminic Acid on Intestinal Microbial Composition and Metabolic Activity in a Piglet Model.Veterinary sciences · 2026Article
- Early-life microbiota disruption-induced deficits in the social brain are sensitive to diet.iScience · 2026Article
- Limited Evidence of Benefits from Clinical Trials of Human-Identical Milk Oligosaccharides for Infants.Advances in nutrition (Bethesda, Md.) · 2026Review
- Gut microbial diversity impacts carbohydrate fermentation by children with severe acute malnutrition.iScience · 2026Article
242 more citing papers are in PubMed but not listed here.
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Authors and funding
25 authors at 7 institutions in 3 countries.
Funding
Abstract
Identifying interventions that more effectively promote healthy growth of children with undernutrition is a pressing global health goal. Analysis of human milk oligosaccharides (HMOs) from 6-month-postpartum mothers in two Malawian birth cohorts revealed that sialylated HMOs are significantly less abundant in those with severely stunted infants. To explore this association, we colonized young germ-free mice with a consortium of bacterial strains cultured from the fecal microbiota of a 6-month-old stunted Malawian infant and fed recipient animals a prototypic Malawian diet with or without purified sialylated bovine milk oligosaccharides (S-BMO). S-BMO produced a microbiota-dependent augmentation of lean body mass gain, changed bone morphology, and altered liver, muscle, and brain metabolism in ways indicative of a greater ability to utilize nutrients for anabolism. These effects were also documented in gnotobiotic piglets using the same consortium and Malawian diet. These preclinical models indicate a causal, microbiota-dependent relationship between S-BMO and growth promotion.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.