ArticleFree radical biology & medicine2016
Yeast mitochondrial glutathione is an essential antioxidant with mitochondrial thioredoxin providing a back-up system.
Article in Free radical biology & medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 54 citations in OpenAlex.
- Mitochondrial redox homeostasis links organellar stress surveillance to germline and somatic integrity in Caenorhabditis elegans.Redox biology · 2026Article
- Tolerance of the non-conventional yeast Wickerhamomyces anomalus BT3 to cadmium exposure: a genomic characterization.Current genetics · 2025Article
- Transcriptome Analysis Reveals the Molecular Mechanism ofAntioxidants (Basel, Switzerland) · 2025Article
- Isa2p is essential inJournal of biosciences · 2025Article
- Xylitol promotes the antioxidant and biocontrol efficiency of the antagonistic yeast,Frontiers in microbiology · 2025Article
- Strategies to Maintain Redox Homeostasis in Yeast Cells with Impaired Fermentation-Dependent NADPH Generation.International journal of molecular sciences · 2024Article
- Glutathione Reductase Expression and Its Prognostic Significance in Colon Cancer.International journal of molecular sciences · 2024Article
- PHB3 Is Required for the Assembly and Activity of Mitochondrial ATP Synthase in Arabidopsis.International journal of molecular sciences · 2023Article
- Hepatoprotective Properties of Water Kefir: A Traditional Fermented Drink and Its Potential Role.International journal of preventive medicine · 2023Review
- Oxidative stress alleviating potential of galactan exopolysaccharide from Weissella confusa KR780676 in yeast model system.Scientific reports · 2022Article
- Yeasts as Complementary Model Systems for the Study of the Pathological Repercussions of Enhanced Synphilin-1 Glycation and Oxidation.International journal of molecular sciences · 2021Article
- Hyperoxidation of mitochondrial peroxiredoxin limits HThe EMBO journal · 2019Article
- Sugar Protectants Improve the Thermotolerance and Biocontrol Efficacy of the Biocontrol Yeast,Frontiers in microbiology · 2019Article
- Heat-induced longevity in budding yeast requires respiratory metabolism and glutathione recycling.Aging · 2018Article
- Metabolome changes are induced in the arbuscular mycorrhizal fungus Gigaspora margarita by germination and by its bacterial endosymbiont.Mycorrhiza · 2018Article
- Ebselen exerts antifungal activity by regulating glutathione (GSH) and reactive oxygen species (ROS) production in fungal cells.Biochimica et biophysica acta. General subjects · 2017Article
- Glutathione reductase gsr-1 is an essential gene required for Caenorhabditis elegans early embryonic development.Free radical biology & medicine · 2016Article
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2 authors at 1 institution in 1 country.
Funding
Abstract
Glutathione is an abundant, low-molecular-weight tripeptide whose biological importance is dependent upon its redox-active free sulphydryl moiety. Its role as the main determinant of thiol-redox control has been challenged such that it has been proposed to play a crucial role in iron-sulphur clusters maturation, and only a minor role in thiol redox regulation, predominantly as a back-up system for the cytoplasmic thioredoxin system. Here, we have tested the importance of mitochondrial glutathione in thiol-redox regulation. Glutathione reductase (Glr1) is an oxidoreductase which converts oxidized glutathione to its reduced form. Yeast Glr1 localizes to both the cytosol and mitochondria and we have used a Glr1(M1L) mutant that is constitutively localized to the cytosol to test the requirement for mitochondrial Glr1. We show that the loss of mitochondrial Glr1 specifically accounts for oxidant sensitivity of a glr1 mutant. Loss of mitochondrial Glr1 does not influence iron-sulphur cluster maturation and we have used targeted roGFP2 fluorescent probes to show that oxidant sensitivity is linked to an altered redox environment. Our data indicate mitochondrial glutathione is crucial for mitochondrial thiol-redox regulation, and the mitochondrial thioredoxin system provides a back-up system, but cannot bear the redox load of the mitochondria on its own.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.