Evidence map›Paper›PMID 26897901›Full record

ArticleJournal of the California Dental Association2016

UCSF Protocol for Caries Arrest Using Silver Diamine Fluoride: Rationale, Indications and Consent.

Jeremy A Horst, Hellene Ellenikiotis, Peter L Milgrom

4 registry-linked trialsAbstract read
PubMed Full text at PMC
In one paragraph

Article in Journal of the California Dental Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 172 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
172citing papers in PubMed, 12 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03770286 nacompletednot on this mapstarted 2019, after this paper: background citation

Treatment of Interproximal Carious Lesions on Primary Molar Teeth With SDF and Super Floss Application Versus SDF Without Super Floss Versus Fluoride Varnish Alone: a Pilot Phase 3 Randomized Controlled Trial

TypeinterventionalSponsorChildren's Hospital Los AngelesRan2019 to 2023Enrolled51ConditionsDental Caries in Children, Dental Caries Class II, Dental CariesArms5% Fluoride Varnish, 38% Silver diamine fluoride, Super Floss
NCT03855527 phase2completednot on this mapstarted 2018, after this paper: background citation

Effectiveness of Silver Diamine Fluoride as Cavity Disinfectant After Atraumatic Restorative Treatment in Primary Teeth: A Randomized Clinical Trial

TypeinterventionalSponsorNourhan M.AlyRan2018 to 2019Enrolled60ConditionsDental CariesArmsSilver Diamine Fluoride, Chlorhexidine, Atraumatic Restorative Treatment without Disinfection
NCT04054635 nacompletednot on this mapstarted 2019, after this paper: background citation

A Randomized Clinical Trial of Silver Diamine Fluoride to Arrest Early Childhood Caries in Young Children

TypeinterventionalSponsorUniversity of ManitobaRan2019 to 2023Enrolled84ConditionsEarly Childhood CariesArmsSilver diamine fluoride
NCT05748067 nacompletednot on this mapstarted 2021, after this paper: background citation

Outcome of Minimally Invasive Treatment for Permanent Molars Affected With Molar-incisor Hypomineralization Defects: a Randomized Clinical Trial

TypeinterventionalSponsorKing Abdullah University HospitalRan2021 to 2025Enrolled73ConditionsMolar Incisor HypomineralizationArmsSDF, HVGIC restoration, SSC
3 · Its place in the literature

Who cites it

172 citing papers in PubMed, 12 syntheses or guidelines pooled it.

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  5. Guideline
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  20. Is Silver Diamine Fluoride Effective in Arresting Enamel Caries? A Randomized Clinical Trial.International journal of environmental research and public health · 2022
    Trial

112 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Jeremy A Horst
Hellene Ellenikiotis
Peter L Milgrom

Funding

UCSF INTEGRATED DDS-PHD TRAINING PROGRAMT32DE007306 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Yukiko Nakano · 1996 to 2026
$15.4M
NIDCR NIH HHS T32 DE007306
6 · The paper itself

Abstract

The Food and Drug Administration recently cleared silver diamine fluoride for reducing tooth sensitivity. Clinical trials document arrest and prevention of dental caries by silver diamine fluoride. This off-label use is now permissible and appropriate under U.S. law. A CDT code was approved for caries arresting medicaments for 2016 to facilitate documentation and billing. We present a systematic review, clinical indications, clinical protocol and consent procedure to guide application for caries arrest treatment.

Indexed as

Cariostatic AgentsClinical ProtocolsDental CariesDentin Desensitizing AgentsFluorides, TopicalHumansOff-Label UseQuaternary Ammonium CompoundsSan FranciscoSilver CompoundsSystematic Reviews as TopicTooth RemineralizationUnited StatesUnited States Food and Drug AdministrationCariostatic AgentsDentin Desensitizing AgentsFluorides, TopicalQuaternary Ammonium CompoundsSilver Compoundssilver diamine fluoride

Identifiers

PMID26897901
PMCPMC4778976

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.