Evidence map›Paper›PMID 26897752›Full record

ReviewMolecular oncology2016

Circulating tumor cell technologies.

Meghaan M Ferreira, Vishnu C Ramani, Stefanie S Jeffrey

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Molecular oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 263 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
263citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

263 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  9. Tumor Metastasis in the Microcirculation.Advances in experimental medicine and biology · 2026
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203 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Meghaan M FerreiraDepartment of Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Vishnu C RamaniDepartment of Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Stefanie S JeffreyDepartment of Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: ssj@stanford.edu.

Funding

A Droplet-Based System for Capture, Manipulation, and Biochemical Profiling of RaR21CA177447 · NCI · STANFORD UNIVERSITY · PI JEFFREY, STEFANIE S. · 2013 to 2014
$525k
NCI NIH HHS R21 CA177447NCI NIH HHS R21CA177447
6 · The paper itself

Abstract

Circulating tumor cells, a component of the "liquid biopsy", hold great potential to transform the current landscape of cancer therapy. A key challenge to unlocking the clinical utility of CTCs lies in the ability to detect and isolate these rare cells using methods amenable to downstream characterization and other applications. In this review, we will provide an overview of current technologies used to detect and capture CTCs with brief insights into the workings of individual technologies. We focus on the strategies employed by different platforms and discuss the advantages of each. As our understanding of CTC biology matures, CTC technologies will need to evolve, and we discuss some of the present challenges facing the field in light of recent data encompassing epithelial-to-mesenchymal transition, tumor-initiating cells, and CTC clusters.

Indexed as

AnimalsCell SeparationCentrifugationElectrophoresisFiltrationHumansLab-On-A-Chip DevicesNeoplasmsNeoplastic Cells, CirculatingAntigen-independent enrichmentCancerCTC captureCTC clustersImmunoaffinity enrichment

Identifiers

PMID26897752
PMCPMC5528969

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.