Evidence map›Paper›PMID 26897269›Full record

ArticleThe American journal of the medical sciences2016

Circulating Progenitor Cells is Linked to Cognitive Decline in Healthy Adults.

Ihab Hajjar, Felicia C Goldstein, Edmund K Waller, Lauren D Moss, Arshed Quyyumi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of the medical sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. CD34Neural regeneration research · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Ihab HajjarDivision of General Internal Medicine and Geriatrics, Department of Medicine, Emory University, Atlanta, Georgia. Electronic address: ihajjar@emory.edu.
Felicia C GoldsteinDepartment of Neurology, Emory University, Atlanta, Georgia.
Edmund K WallerDepartment of Hematology/Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia.
Lauren D MossProgram Management Associate, Sarah Cannon Research Institute, Nashville, Tennessee.
Arshed QuyyumiDivision of Cardiology, Department of Medicine, Emory University, Atlanta, Georgia.
Emory University · USSarah Cannon · US

Funding

Atlanta Clinical and Translational Science Institute (ACTSI) RenewalUL1TR000454 · NCATS · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2012 to 2016
$25.8M
The role of the renin-angiotensin-endothelial pathway in ADRF1AG051633 · NIA · EMORY UNIVERSITY · PI HAJJAR, IHAB M, QUYYUMI, ARSHED A · 2015 to 2017
$6.0M
Hypertension, angiotensin receptor blockers, and cognition: effects and mechanismR01AG042127 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HAJJAR, IHAB M · 2012 to 2017
$3.0M
NCATS NIH HHS UL1 TR000454NCATS NIH HHS UL1TR000454NIA NIH HHS R01 AG042127NIA NIH HHS R01AG042127NIA NIH HHS RF1 AG051633
6 · The paper itself

Abstract

objectiveCognitive and cardiovascular disorders share many risk factors. Higher bone-marrow derived progenitor cells (PC) in blood are associated with lower rates of cardiovascular events but the association of PC with cognitive function is unclear. The objective of this study was to assess the association between PC and cognition in a sample of healthy adults enrolled in a cohort study. MATERIALS AND

methodsA random sample of employees at Emory University and Georgia Institute of Technology were followed for 4 years and underwent yearly vascular and cognitive assessment (N = 430, mean age = 49.2 years, 70% women, and 27% African-American). Cognition was assessed using computerized versions of 15 cognitive tests and principal component analysis was used for deriving cognitive scores: executive function, memory and working memory. PC were defined as mononuclear cells with specific surface markers (7 phenotypes). Decreased cognition in a domain was defined as performing below the lowest quartile for the corresponding domain at baseline. Generalized estimating equations were used to investigate associations between PC and cognition.

resultsHigher PC levels at baseline were associated with lower risk of cognitive decline in the executive and working memory domains during the follow-up period (P < 0.002 for all PC phenotypes). Further, the degree of decline in PC over the follow-up period was correlated with a corresponding decline in performances in all 3 cognitive domains over the same period (All P < 0.002).

conclusionLower PC and greater yearly declines in PC are associated with greater cognitive decline. These findings suggest the role for PC in neurocognitive aging.

Indexed as

CognitionExecutive FunctionMemoryCognition DisordersCohort StudiesFemaleGeorgiaHumansMaleMemory, Short-TermMiddle AgedRisk FactorsStem CellsCognitive functionMemoryPre-eclampsiaProgenitor cells

Identifiers

PMID26897269
PMCPMC4762175
OpenAlexW2275443297

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.