ReviewJournal of nephrology2016
Focal segmental glomerular sclerosis: do not overlook the role of immune response.
Review in Journal of nephrology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 18 citations in OpenAlex.
- Single-cell transcriptomics and machine-learning reveal M1 macrophage-driven progression from minimal change disease to focal segmental glomerulosclerosis.Renal failure · 2026Article
- The role of toll-like receptors (TLRs) and their therapeutic applications in glomerulonephritis.International urology and nephrology · 2023Review
- Perturbations in podocyte transcriptome and biological pathways induced by FSGS associated circulating factors.Annals of translational medicine · 2023Article
- Understanding the podocyte immune responses in proteinuric kidney diseases: from pathogenesis to therapy.Frontiers in immunology · 2023Review
- The podocyte: glomerular sentinel at the crossroads of innate and adaptive immunity.Frontiers in immunology · 2023Review
- Toll-Like Receptor as a Potential Biomarker in Renal Diseases.International journal of molecular sciences · 2020Review
- IL-17 aggravates renal injury by promoting podocyte injury in children with primary nephrotic syndrome.Experimental and therapeutic medicine · 2020Article
- Autoimmunity in Focal Segmental Glomerulosclerosis: A Long-Standing Yet Elusive Association.Frontiers in medicine · 2020Review
- JAK-STAT signaling is activated in the kidney and peripheral blood cells of patients with focal segmental glomerulosclerosis.Kidney international · 2018Article
- FSGS: from pathogenesis to the histological lesion.Journal of nephrology · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Focal and segmental glomerular sclerosis (FSGS) is a histological pattern characterized by the partial sclerosis of some, but not all, glomeruli. It may be secondary to diverse etiologies such as mutations of podocyte key genes, loss of nephrons, drugs, and virus infection. However, in most cases of FSGS, the etiology is unknown and these forms are called idiopathic (primary) FSGS. A number of different pathogenic hypotheses have been proposed. The frequent recurrence of nephrotic proteinuria after renal transplantation has attracted the attention to search for plasma factors eventually implicated in the pathogenesis. However a decisive and unifying hypothesis is still lacking. On the other hand, recent findings indicate the involvement of cellular immunity and possibly autoantibodies in the pathogenesis of some forms of FSGS. In this paper we report on the recent advances in the pathophysiology of idiopathic FSGS and suggest the possibility that at least some forms of idiopathic FSGS may be caused by autoimmune reactivity.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.