ArticlePlant physiology2016
Integration of Experiments across Diverse Environments Identifies the Genetic Determinants of Variation in Sorghum bicolor Seed Element Composition.
Article in Plant physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- Meta-analysis identifies pleiotropic loci controlling phenotypic trade-offs in sorghum.Genetics · 2021Pooled it
- A comparative approach for selecting orthologous candidate genes in genome-wide association studies across multiple species.Plant physiology · 2026Article
- Genome-wide association analysis reveals genetic variations and candidate genes associated with tannin and starch contents in sorghum.BMC genomics · 2026Article
- Modeling grain biochemical composition traits of commercial sorghum hybrids under diverse management practices.Frontiers in plant science · 2026Article
- Genome-Wide Association Studies Reveal the Genetic Architecture of Ionomic Variation in Grains of Tartary Buckwheat.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Genome-wide association study and expression of candidate genes for Fe and Zn concentration in sorghum grains.Scientific reports · 2024Article
- Calcium modulation of bacterial wilt disease on potato.Applied and environmental microbiology · 2024Article
- Genetic and genomic interventions in crop biofortification: Examples in millets.Frontiers in plant science · 2023Review
- Temporal and environmental factors interact with rootstock genotype to shape leaf elemental composition in grafted grapevines.Plant direct · 2022Article
- SorghumBase: a web-based portal for sorghum genetic information and community advancement.Planta · 2022Article
- Genetic determinants of micronutrient traits in graminaceous crops to combat hidden hunger.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2021Review
- Genetic architecture of root and shoot ionomes in rice (Oryza sativa L.).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2021Article
- Ionomic Approaches for Discovery of Novel Stress-Resilient Genes in Plants.International journal of molecular sciences · 2021Review
- Sorghum breeding in the genomic era: opportunities and challenges.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2021Review
- Review
- High-resolution genome-wide association study pinpoints metal transporter and chelator genes involved in the genetic control of element levels in maize grain.G3 (Bethesda, Md.) · 2021Article
- Specificity and Plasticity of the Functional Ionome ofFrontiers in plant science · 2021Article
- Comprehensive 3D phenotyping reveals continuous morphological variation across genetically diverse sorghum inflorescences.The New phytologist · 2020Article
- Genome-wide association study reveals that different pathways contribute to grain quality variation in sorghum (Sorghum bicolor).BMC genomics · 2020Article
- Multivariate analysis reveals environmental and genetic determinants of element covariation in the maize grain ionome.Plant direct · 2019Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Seedling establishment and seed nutritional quality require the sequestration of sufficient element nutrients. The identification of genes and alleles that modify element content in the grains of cereals, including sorghum (Sorghum bicolor), is fundamental to developing breeding and selection methods aimed at increasing bioavailable element content and improving crop growth. We have developed a high-throughput work flow for the simultaneous measurement of multiple elements in sorghum seeds. We measured seed element levels in the genotyped Sorghum Association Panel, representing all major cultivated sorghum races from diverse geographic and climatic regions, and mapped alleles contributing to seed element variation across three environments by genome-wide association. We observed significant phenotypic and genetic correlation between several elements across multiple years and diverse environments. The power of combining high-precision measurements with genome-wide association was demonstrated by implementing rank transformation and a multilocus mixed model to map alleles controlling 20 element traits, identifying 255 loci affecting the sorghum seed ionome. Sequence similarity to genes characterized in previous studies identified likely causative genes for the accumulation of zinc, manganese, nickel, calcium, and cadmium in sorghum seeds. In addition to strong candidates for these five elements, we provide a list of candidate loci for several other elements. Our approach enabled the identification of single-nucleotide polymorphisms in strong linkage disequilibrium with causative polymorphisms that can be evaluated in targeted selection strategies for plant breeding and improvement.
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