ArticleGenetics2016
The Genetic Basis of Haploid Induction in Maize Identified with a Novel Genome-Wide Association Method.
Article in Genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
- Production of Homozygous Maize Lines Using Maternal Haploid Inducer Lines.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Decades' progress and prospects on maize functional genomics and molecular breeding.Science China. Life sciences · 2025Review
- Revolutionizing molecular plant breeding through genetic engineering of in vivo haploid induction genes.Molecular biology reports · 2025Review
- In vitro- and in vivo-based approaches for doubled haploid production in Zea mays L.: challenges and opportunities.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Review
- The haploid induction ability analysis of various mutation of OsMATL and OsDMPs in rice.BMC biology · 2025Article
- Genes and genetics belong to maize haploid induction.Frontiers in plant science · 2025Review
- Allelic variation and haplotype diversity ofPhysiology and molecular biology of plants : an international journal of functional plant biology · 2024Article
- Genetic Diversity within a Collection of Italian Maize Inbred Lines: A Resource for Maize Genomics and Breeding.Plants (Basel, Switzerland) · 2024Article
- Haploid identification in maize.Frontiers in plant science · 2024Review
- Accelerating haploid induction rate and haploid validation through marker-assisted selection forFrontiers in plant science · 2024Article
- DNA-free genome editing forGM crops & food · 2023Article
- High-throughput haploid induction in species with bisexual flowers.Plant communications · 2023Article
- Genetic basis of maize maternal haploid induction beyondFrontiers in plant science · 2023Article
- Recent Advances in Engineering of In Vivo Haploid Induction Systems.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Protocols for In Vivo Doubled Haploid (DH) Technology in Maize Breeding: From Haploid Inducer Development to Haploid Genome Doubling.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Loss-of-function alleles of ZmPLD3 cause haploid induction in maize.Nature plants · 2021Article
- Review
- Maize In Planta Haploid Inducer Lines: A Cornerstone for Doubled Haploid Technology.Methods in molecular biology (Clifton, N.J.) · 2021Review
- Species with Haploid or Doubled Haploid Protocols.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Article
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17 authors.
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No grant is acknowledged in the PubMed record.
Abstract
In vivo haploid induction (HI) triggered by pollination with special intraspecific genotypes, called inducers, is unique to Zea maysL. within the plant kingdom and has revolutionized maize breeding during the last decade. However, the molecular mechanisms underlying HI in maize are still unclear. To investigate the genetic basis of HI, we developed a new approach for genome-wide association studies (GWAS), termed conditional haplotype extension (CHE) test that allows detection of selective sweeps even under almost perfect confounding of population structure and trait expression. Here, we applied this test to identify genomic regions required for HI expression and dissected the combined support interval (50.34 Mb) of the QTL qhir1, detected in a previous study, into two closely linked genomic segments relevant for HI expression. The first, termed qhir11(0.54 Mb), comprises an already fine-mapped region but was not diagnostic for differentiating inducers and noninducers. The second segment, termed qhir12(3.97 Mb), had a haplotype allele common to all 53 inducer lines but not found in any of the 1482 noninducers. By comparing resequencing data of one inducer with 14 noninducers, we detected in the qhir12 region three candidate genes involved in DNA or amino acid binding, however, none for qhir11 We propose that the CHE test can be utilized in introgression breeding and different fields of genetics to detect selective sweeps in heterogeneous genetic backgrounds.
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