Evidence map›Paper›PMID 26896268›Full record

ArticleIndian heart journal

Multimarker risk stratification approach and cardiovascular outcomes in patients with stable coronary artery disease undergoing elective percutaneous coronary intervention.

Vimal Mehta, Rishi Sukhija, Pratishtha Mehra, Anuj Goyal, Jamal Yusuf, Bhawna Mahajan, V K Gupta, Sanjay Tyagi, Chandrasekar Palaniswamy, Wilbert S Aronow

Abstract read
In one paragraph

Article in Indian heart journal. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Vimal MehtaDepartment of Cardiology, G.B. Pant Hospital, Delhi, India.
Rishi SukhijaDepartment of Medicine, Division of Cardiology, IU Health La Porte Hospital, IN, United States.
Pratishtha MehraDepartment of Cardiology, G.B. Pant Hospital, Delhi, India.
Anuj GoyalDepartment of Cardiology, G.B. Pant Hospital, Delhi, India.
Jamal YusufDepartment of Cardiology, G.B. Pant Hospital, Delhi, India.
Bhawna MahajanDepartment of Biochemistry, G.B. Pant Hospital, Delhi, India.
V K GuptaDepartment of Biochemistry, G.B. Pant Hospital, Delhi, India.
Sanjay TyagiDepartment of Cardiology, G.B. Pant Hospital, Delhi, India.
Chandrasekar PalaniswamyDepartment of Medicine, Division of Cardiology, Mount Sinai Hospital, NY, United States. Electronic address: chandrasekar.palaniswamy@mountsinai.org.
Wilbert S AronowDepartment of Medicine, Division of Cardiology, New York Medical College at Westchester Medical Center, Valhalla, NY, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsWe studied the utility of multimarker risk stratification approach to predict cardiovascular outcomes in patients with stable coronary artery disease, undergoing elective percutaneous coronary intervention (PCI).

methodsWe prospectively evaluated 302 consecutive patients with stable coronary artery disease and normal CPK-MB and cardiac troponin T levels, and who underwent elective PCI at our institution. The following cardiac biomarkers were measured before and between 12 and 24h post-procedure: CK-MB, cardiac troponin T, hs-CRP, and NT-ProBNP. Patients were followed up for a minimum of 6 months.

resultsPost-PCI, CPK-MB levels were elevated but below myocardial infarction (MI) range in 70 patients (23%), and in the MI range in 6 patients (2%). Troponin T levels were detectable but below the 99th percentile (microleak) in 32 patients (10.6%) and elevated above the 99th percentile (periprocedural MI) in 104 patients (34.4%). At 9 months' follow-up, 1% died, 2% had stable angina, 10.3% had non-fatal MI, and 87.7% remained asymptomatic. There was no significant difference in clinical events among groups stratified by elevation of one biomarker or multiple biomarkers.

conclusionSingle or multiple biomarker strategy in patients with normal baseline biomarkers failed to predict major cardiac events after PCI over medium-term follow-up.

Indexed as

Percutaneous Coronary InterventionBiomarkersCause of DeathCoronary Artery DiseaseC-Reactive ProteinCreatine Kinase, MB FormElective Surgical ProceduresFemaleFollow-Up StudiesHumansIncidenceIndiaMaleMiddle AgedProspective StudiesRisk AssessmentBiomarkersC-Reactive ProteinCreatine Kinase, MB FormTroponin TBiomarkersMajor adverse cardiovascular eventPercutaneous coronary interventionPeriprocedural myocardial infarction

Identifiers

PMID26896268
PMCPMC4759483

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