Trial reportThe Journal of allergy and clinical immunology2016
Enquiring About Tolerance (EAT) study: Feasibility of an early allergenic food introduction regimen.
Trial report in The Journal of allergy and clinical immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07321522 (Early Introduction and Sustained Ingestion), which is not on this map. Cited by 78 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Early Introduction and Sustained Ingestion (EISI) Using Two Educational Opportunities - A Pilot Study
Who cites it
78 citing papers in PubMed, 2 syntheses or guidelines pooled it, 207 citations in OpenAlex.
- Complementary Feeding: Recommendations for the Introduction of Allergenic Foods and Gluten in the Preterm Infant.Nutrients · 2021Pooled it
- Early additional food and fluids for healthy breastfed full-term infants.The Cochrane database of systematic reviews · 2016Pooled it
- Trial
- Early introduction of peanut reduces peanut allergy across risk groups in pooled and causal inference analyses.Allergy · 2023Trial
- Association of frequent moisturizer use in early infancy with the development of food allergy.The Journal of allergy and clinical immunology · 2021Trial
- Gut microbiota development during infancy: Impact of introducing allergenic foods.The Journal of allergy and clinical immunology · 2021Trial
- A randomized trial of the acceptability of a daily multi-allergen food supplement for infants.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2020Trial
- Factors influencing adherence in a trial of early introduction of allergenic food.The Journal of allergy and clinical immunology · 2019Trial
- Efficacy of the Enquiring About Tolerance (EAT) study among infants at high risk of developing food allergy.The Journal of allergy and clinical immunology · 2019Trial
- Association of Early Introduction of Solids With Infant Sleep: A Secondary Analysis of a Randomized Clinical Trial.JAMA pediatrics · 2018Trial
- Early Risk Assessment and Recognition of Allergies in Children: Rationale, Methodology, and Proposed Algorithms.Allergy · 2026Review
- Early Peanut Introduction for Allergy Prevention: Evidence and Practical Implementation in Pediatric Practice.Cureus · 2026Review
- Article
- Early Allergen Introduction in Delaware: A Model to Address Healthcare Disparities and Population Healthcare Costs.Cureus · 2026Review
- Early Walnut Powder Introduction for Prevention of Walnut Sensitisation in High-Risk Infants With Eczema: An Open-Label, Randomised, Non-Inferiority Trial.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2026Article
- A retrospective cohort study of supervised and home baked and/or neat hen's egg challenge for pediatric IgE hen's egg allergy.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026Article
- Micronutrient status and growth outcomes in children with cow's milk allergy: beyond elimination diets.Frontiers in nutrition · 2026Review
- Living with Food Allergy in Adolescence: The Nutritional and Psychological Impact of Allergen Avoidance.Nutrients · 2025Review
- Eating away at food allergy.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2025Review
- Observational
18 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe influence of early exposure to allergenic foods on the subsequent development of food allergy remains uncertain.
objectiveWe sought to determine the feasibility of the early introduction of multiple allergenic foods to exclusively breast-fed infants from 3 months of age and the effect on breastfeeding performance.
methodsWe performed a randomized controlled trial. The early introduction group (EIG) continued breastfeeding with sequential introduction of 6 allergenic foods: cow's milk, peanut, hard-boiled hen's egg, sesame, whitefish (cod), and wheat; the standard introduction group followed the UK infant feeding recommendations of exclusive breastfeeding for around 6 months with no introduction of allergenic foods before 6 months of age.
resultsOne thousand three hundred three infants were enrolled. By 5 months of age, the median frequency of consumption of all 6 foods was 2 to 3 times per week for every food in the EIG and no consumption for every food in the standard introduction group (P < .001 for every comparison). By 6 months of age, nonintroduction of the allergenic foods in the EIG was less than 5% for each of the 6 foods. Achievement of the stringent per-protocol consumption target for the EIG proved more difficult (42% of evaluable EIG participants). Breastfeeding rates in both groups significantly exceeded UK government data for equivalent mothers (P < .001 at 6 and at 9 months of age).
conclusionEarly introduction, before 6 months of age, of at least some amount of multiple allergenic foods appears achievable and did not affect breastfeeding. This has important implications for the evaluation of food allergy prevention strategies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.