Impaired Neurodevelopmental Outcomes in Very Preterm Infants: Much Too Easy to Blame It Just on Morphine!

Johannes N van den Anker, Monique van Dijk, Dick Tibboel

Abstract readEditorialComment

In one paragraph

Article in The Journal of pediatrics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

Neurodevelopmental outcomes at five years in children born very preterm (24-31 weeks) exposed to opioids with or without midazolam: results from the French nationwide EPIPAGE-2 cohort study.The Lancet regional health. Europe · 2025
Article
Association between opioid use during mechanical ventilation in preterm infants and evidence of brain injury: a propensity score-matched cohort study.EClinicalMedicine · 2023
Article

4 · The record

Corrections and comments

Comment on
Smaller Cerebellar Growth and Poorer Neurodevelopmental Outcomes in Very Preterm Infants Exposed to Neonatal Morphine.2016

5 · Who and what money

Authors and funding

3 authors.

Johannes N van den AnkerDivision of Pediatric Clinical Pharmacology, Children's National Health System, Washington, DC; Departments of Pediatrics, Integrative Systems Biology, Pharmacology, and Physiology, George Washington University School of Medicine and Health Sciences, Washington, DC; George Washington University School of Medicine and Health Sciences, Washington, DC; Division of Pediatric Pharmacology and Pharmacometrics, University of Basel Children's Hospital, Basel, Switzerland; Intensive Care and Department of Pediatric Surgery, Erasmus Medical Center-Sophia Children's Hospital, Rotterdam, The Netherlands. Electronic address: jvandena@cnmc.org.

Monique van DijkIntensive Care and Department of Pediatric Surgery, Erasmus Medical Center-Sophia Children's Hospital, Rotterdam, The Netherlands.

Dick TibboelIntensive Care and Department of Pediatric Surgery, Erasmus Medical Center-Sophia Children's Hospital, Rotterdam, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Infant, Very Low Birth WeightMorphineHumansInfantInfant, NewbornInfant, PrematureInfant, Premature, DiseasesMorphine

Identifiers

PMID26896158

DOI10.1016/j.jpeds.2016.01.071

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.