ArticleApplied and environmental microbiology2016
Effect of Dietary Oxalate on the Gut Microbiota of the Mammalian Herbivore Neotoma albigula.
Article in Applied and environmental microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 49 citations in OpenAlex.
- Predicting probiotic success: lessons from Oxalobacter and oxalate metabolism.NPJ biofilms and microbiomes · 2026Review
- Complex system modeling reveals oxalate homeostasis is driven by diverse oxalate-degrading bacteria.eLife · 2025Article
- Population Dynamics and the Microbiome in a Wild Boreal Mammal: The Snowshoe Hare Cycle and Impacts of Diet, Season and Predation Risk.Molecular ecology · 2025Article
- A microbiota-based perspective on urinary stone disease: insights from 16S rRNA sequencing and machine learning models.Frontiers in cellular and infection microbiology · 2025Article
- Mechanism of Nephrolithiasis: Does the Microbiome Play a Role?European urology focus · 2024Review
- Multiomics Assessment of the Gut Microbiome in Rare Hyperoxaluric Conditions.Kidney international reports · 2024Article
- Seasonal dynamics in the mammalian microbiome between disparate environments.Ecology and evolution · 2023Article
- Dynamics of rumen microbiome in sika deer (Cervus nippon yakushimae) from unique subtropical ecosystem in Yakushima Island, Japan.Scientific reports · 2022Article
- Analysis and Characterization of Lactobacillus paragasseri and Lacticaseibacillus paracasei: Two Probiotic Bacteria that Can Degrade Intestinal Oxalate in Hyperoxaluric Rats.Probiotics and antimicrobial proteins · 2022Article
- Demonstrating the role of symbionts in mediating detoxification in herbivores.Symbiosis (Philadelphia, Pa.) · 2022Article
- Microbiome stability and structure is governed by host phylogeny over diet and geography in woodrats (Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- The microbiome extends host evolutionary potential.Nature communications · 2021Review
- Diet-induced oxalate nephropathy from excessive nut and seed consumption.BMJ case reports · 2020Article
- Calcium Oxalate Nephrolithiasis and Gut Microbiota: Not just a Gut-Kidney Axis. A Nutritional Perspective.Nutrients · 2020Review
- Effect of dietary gossypol supplement on fermentation characteristics and bacterial diversity in the rumen of sheep.PloS one · 2020Article
- Natural diets promote retention of the native gut microbiota in captive rodents.The ISME journal · 2020Article
- Inhibition of urinary stone disease by a multi-species bacterial network ensures healthy oxalate homeostasis.Kidney international · 2019Article
- Loss of function dysbiosis associated with antibiotics and high fat, high sugar diet.The ISME journal · 2019Article
- Defining Dysbiosis in Patients with Urolithiasis.Scientific reports · 2019Article
- Dietary oxalate and kidney stone formation.American journal of physiology. Renal physiology · 2019Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Diet is one of the primary drivers that sculpts the form and function of the mammalian gut microbiota. However, the enormous taxonomic and metabolic diversity held within the gut microbiota makes it difficult to isolate specific diet-microbe interactions. The objective of the current study was to elucidate interactions between the gut microbiota of the mammalian herbivore Neotoma albigula and dietary oxalate, a plant secondary compound (PSC) degraded exclusively by the gut microbiota. We quantified oxalate degradation in N. albigula fed increasing amounts of oxalate over time and tracked the response of the fecal microbiota using high-throughput sequencing. The amount of oxalate degraded in vivo was linearly correlated with the amount of oxalate consumed. The addition of dietary oxalate was found to impact microbial species diversity by increasing the representation of certain taxa, some of which are known to be capable of degrading oxalate (e.g., Oxalobacter spp.). Furthermore, the relative abundances of 117 operational taxonomic units (OTU) exhibited a significant correlation with oxalate consumption. The results of this study indicate that dietary oxalate induces complex interactions within the gut microbiota that include an increase in the relative abundance of a community of bacteria that may contribute either directly or indirectly to oxalate degradation in mammalian herbivores.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.