ArticleSurgical endoscopy2016
Predictors for regional lymph node metastasis in T1 rectal cancer: a population-based SEER analysis.
Article in Surgical endoscopy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Executive Summary of the American Radium Society Appropriate Use Criteria for Local Excision in Rectal Cancer.International journal of radiation oncology, biology, physics · 2019Guideline
- International expert Delphi consensus on management of early and locally advanced rectal cancer.International journal of colorectal disease · 2025Article
- The Potential Health Economic Value of Adding Magnetomotive Ultrasound to Current Diagnostic Methods for Detecting Lymph Node Metastases in Rectal Cancer.PharmacoEconomics · 2025Article
- Comparative microRNA signatures based on liquid biopsy to identify lymph node metastasis in T1 colorectal cancer patients undergoing upfront surgery or endoscopic resection.Cell death discovery · 2025Article
- Analysis of Risk Factors and Development of a Predictive Model for Prognosis in Early-Stage Rectal Cancer Patients.International journal of general medicine · 2025Article
- Article
- Development and validation of a competitive risk model in patients with rectal cancer: based on SEER database.European journal of medical research · 2023Article
- Prediction of lymph node metastasis in stage T1-2 rectal cancers with MRI-based deep learning.European radiology · 2023Article
- The risk-benefit trade-off in local excision of early rectal cancer.Annals of coloproctology · 2022Article
- Clinicopathological features of small T1 colorectal cancers.World journal of clinical cases · 2021Article
- A Liquid Biopsy Assay for Noninvasive Identification of Lymph Node Metastases in T1 Colorectal Cancer.Gastroenterology · 2021Article
- Association Between Chemotherapy and Survival in T1 Colon Cancer With Lymph Node Metastasis: A Propensity-Score Matched Analysis.Frontiers in oncology · 2021Article
- The correlation between tumor size, lymph node status, distant metastases and mortality in rectal cancer patients without neoadjuvant therapy.Journal of Cancer · 2021Article
- Preoperative Predictors of Lymph Node Metastasis in Colon Cancer.Frontiers in oncology · 2021Article
- Influence of Old Age on Risk of Lymph Node Metastasis and Survival in Patients With T1 Colorectal Cancer: A Population-Based Analysis.Frontiers in oncology · 2021Article
- Population-based analysis on predictors for lymph node metastasis in T1 colon cancer.Surgical endoscopy · 2020Article
- Histological grades of rectal cancer: whole-volume histogram analysis of apparent diffusion coefficient based on reduced field-of-view diffusion-weighted imaging.Quantitative imaging in medicine and surgery · 2020Article
- Article
- A MicroRNA Signature Associated With Metastasis of T1 Colorectal Cancers to Lymph Nodes.Gastroenterology · 2018Article
- Management of complex polyps of the colon and rectum.International journal of colorectal disease · 2018Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLocal resection of early-stage rectal cancer significantly reduces perioperative morbidity compared with radical resection. Identifying patients at risk of regional lymph node metastasis (LNM) is crucial for long-term survival after local resection.
methodsPatients after oncological resection of T1 rectal cancer were identified in the Surveillance, Epidemiology, and End Results register 2004-2012. Potential predictors of LNM and its impact on cancer-specific survival were assessed in logistic and Cox regression with and without multivariable adjustment.
resultsIn total, 1593 patients with radical resection of T1 rectal cancer and a minimum of 12 retrieved regional lymph nodes were identified. The overall LNM rate was 16.3 % (N = 260). A low risk of LNM was observed for small tumor size (P = 0.002), low tumor grade (P = 0.002) and higher age (P = 0.012) in multivariable analysis. The odds ratio for a tumor size exceeding 1.5 cm was 1.49 [95 % confidence interval (CI) 1.06-2.13], for G2 and G3/G4 carcinomas 1.69 (95 % CI 1.07-2.82) and 2.72 (95 % CI 1.50-5.03), and for 65- to 79-year-old and over 80-year-old patients 0.65 (95 % CI 0.43-0.96) and 0.39 (95 % CI 0.18-0.77), respectively. Five-year cancer-specific survival for patients with LNM was 90.0 % (95 % CI 85.3-95.0 %) and for patients without LNM 97.1 % (95 % CI 95.9-98.2 %, hazard ratio = 3.21, 95 % CI 1.82-5.69, P < 0.001).
conclusionsIn this population-based analysis, favorable cancer-specific survival rates were observed in nodal-negative and nodal-positive T1 rectal cancer patients after primary radical resection. The predictive value of tumor size, grading and age for LNM should be considered in medical decision making about local resection.
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