ArticleNucleic acids research2016
Delineation of metabolic gene clusters in plant genomes by chromatin signatures.
Article in Nucleic acids research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 81 citations in OpenAlex.
- Functional Characterization and Promoter Analysis of a MeJA-Responsive Squalene Synthase GeneInternational journal of molecular sciences · 2026Article
- Somatic mobility of transposons is explosive and shaped by distinct integration biases in Arabidopsis thaliana.Genome biology · 2026Article
- CUT&Tag Epigenomic Profiling of Biosynthetic Gene Clusters in Arabidopsis thaliana.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Characterization of the Cannabis sativa glandular trichome epigenome.BMC plant biology · 2024Article
- Enhancing Withanolide Production in thePlants (Basel, Switzerland) · 2024Review
- Tomato root specialized metabolites evolved through gene duplication and regulatory divergence within a biosynthetic gene cluster.Science advances · 2024Article
- Coregulatory effects of multiple histone modifications in key ferroptosis-related genes for lung adenocarcinoma.Epigenomics · 2024Article
- Disease resistance conferred by components of essential chrysanthemum oil and the epigenetic regulation of OsTPS1.Science China. Life sciences · 2023Article
- Uncovering a miltiradiene biosynthetic gene cluster in the Lamiaceae reveals a dynamic evolutionary trajectory.Nature communications · 2023Article
- Analysis of Arabidopsis non-reference accessions reveals high diversity of metabolic gene clusters and discovers new candidate cluster members.Frontiers in plant science · 2023Article
- Functional diversity and metabolic engineering of plant-specialized metabolites.Life metabolism · 2022Review
- Integrative omics approaches for biosynthetic pathway discovery in plants.Natural product reports · 2022Review
- Plant biosynthetic gene clusters in the context of metabolic evolution.Natural product reports · 2022Review
- Unlocking plant metabolic diversity: A (pan)-genomic view.Plant communications · 2022Review
- Review
- Multi-Omics-Based Discovery of Plant Signaling Molecules.Metabolites · 2022Review
- Adaptive mechanisms of plant specialized metabolism connecting chemistry to function.Nature chemical biology · 2021Review
- Mining genomes to illuminate the specialized chemistry of life.Nature reviews. Genetics · 2021Review
- The emerging role of biosynthetic gene clusters in plant defense and plant interactions.PLoS pathogens · 2021Review
- Subtelomeric assembly of a multi-gene pathway for antimicrobial defense compounds in cereals.Nature communications · 2021Article
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
Plants are a tremendous source of diverse chemicals, including many natural product-derived drugs. It has recently become apparent that the genes for the biosynthesis of numerous different types of plant natural products are organized as metabolic gene clusters, thereby unveiling a highly unusual form of plant genome architecture and offering novel avenues for discovery and exploitation of plant specialized metabolism. Here we show that these clustered pathways are characterized by distinct chromatin signatures of histone 3 lysine trimethylation (H3K27me3) and histone 2 variant H2A.Z, associated with cluster repression and activation, respectively, and represent discrete windows of co-regulation in the genome. We further demonstrate that knowledge of these chromatin signatures along with chromatin mutants can be used to mine genomes for cluster discovery. The roles of H3K27me3 and H2A.Z in repression and activation of single genes in plants are well known. However, our discovery of highly localized operon-like co-regulated regions of chromatin modification is unprecedented in plants. Our findings raise intriguing parallels with groups of physically linked multi-gene complexes in animals and with clustered pathways for specialized metabolism in filamentous fungi.
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