SynthesisBMC public health2016
Factors influencing completion of multi-dose vaccine schedules in adolescents: a systematic review.
Synthesis in BMC public health, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 7 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
50 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- Comparative effectiveness and immunogenicity of single-dose and multi-dose human papillomavirus vaccination: a systematic review.BMC public health · 2025Pooled it
- Uptake of human papilloma virus vaccine and its determinants among females in East Africa: a systematic review and meta-analysis.BMC public health · 2024Pooled it
- Pooled it
- Barriers and Factors Associated with HPV Vaccination Among American Indians and Alaska Natives: A Systematic Review.Journal of community health · 2022Pooled it
- Barriers to Human Papillomavirus Vaccine Uptake Among Racial/Ethnic Minorities: a Systematic Review.Journal of racial and ethnic health disparities · 2021Pooled it
- Rotavirus vaccination in the US: a systematic review of vaccination coverage and completion.Human vaccines & immunotherapeutics · 2021Pooled it
- Factors associated with adolescent HPV vaccination in the U.S.: A systematic review of reviews and multilevel framework to inform intervention development.Preventive medicine · 2020Pooled it
- Social and behavioral predictors of two-doses 4CMenB vaccine series among adolescents enrolled in a cluster randomized controlled trial in Australia.Human vaccines & immunotherapeutics · 2022Trial
- Factors associated with vaccination completion and retention among HIV negative female sex workers enrolled in a simulated vaccine efficacy trial in Kampala, Uganda.BMC infectious diseases · 2019Trial
- Socioeconomic inequality in recommended childhood vaccinations in Germany: evidence from insurance claims and concentration index decomposition.BMC medicine · 2026Article
- Adult adherence to multi-dose vaccine schedules: A population-based assessment of guideline concordance.Public health in practice (Oxford, England) · 2026Article
- The impacts of COVID-19 on routine immunization for children in Rwanda.BMC infectious diseases · 2026Article
- Article
- The relationship between socio-economic inequity indicators and 4CMenB vaccination rates in infants and adolescents in Spain: An ecological correlation study.Human vaccines & immunotherapeutics · 2025Article
- Regional Alliance for Cervical Cancer Prevention in Eastern Europe and Central Asia: Progressing Towards the Target 1 of the Global Strategy for Cervical Cancer Elimination.Healthcare (Basel, Switzerland) · 2025Article
- Article
- Factors associated with human papilloma virus vaccine uptake before the health awareness, learning and education intervention in Korogocho Informal Settlements in Nairobi County, Kenya.Ecancermedicalscience · 2025Article
- Communication Interactions, Needs, and Preferences During Clinical Encounters of African American Parent-Child Dyads.Journal of racial and ethnic health disparities · 2024Article
- Immunogenicity and Safety of a Quadrivalent Meningococcal Conjugate Vaccine Versus Nimenrix in Healthy Adolescents: A Randomized Phase IIIb Multicenter Study.Infectious diseases and therapy · 2024Article
- State and territory immunization program activities and their association with human papillomavirus vaccine initiation in the United States of America: A multilevel approach.PLOS global public health · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCompletion of multiple dose vaccine schedules is crucial to ensure a protective immune response, and maximise vaccine cost-effectiveness. While barriers and facilitators to vaccine uptake have recently been reviewed, there is no comprehensive review of factors influencing subsequent adherence or completion, which is key to achieving vaccine effectiveness. This study identifies and summarises the literature on factors affecting completion of multi-dose vaccine schedules by adolescents.
methodsTen online databases and four websites were searched (February 2014). Studies with analysis of factors predicting completion of multi-dose vaccines were included. Study participants within 9-19 years of age were included in the review. The defined outcome was completion of the vaccine series within 1 year among those who received the first dose.
resultsOverall, 6159 abstracts were screened, and 502 full texts were reviewed. Sixty one studies were eligible for this review. All except two were set in high-income countries. Included studies evaluated human papillomavirus vaccine, hepatitis A, hepatitis B, and varicella vaccines. Reported vaccine completion rates, among those who initiated vaccination, ranged from 27% to over 90%. Minority racial or ethnic groups and inadequate health insurance coverage were risk factors for low completion, irrespective of initiation rates. Parental healthcare seeking behaviour was positively associated with completion. Vaccine delivery in schools was associated with higher completion than delivery in the community or health facilities. Gender, prior healthcare use and socio-economic status rarely remained significant risks or protective factors in multivariate analysis.
conclusionsAlmost all studies investigating factors affecting completion have been carried out in developed countries and investigate a limited range of variables. Increased understanding of barriers to completion in adolescents will be invaluable to future new vaccine introductions and the further development of an adolescent health platform. PROSPERO reg# CRD42014006765.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.