Evidence map›Paper›PMID 26895421›Full record

ArticleMolecular cell2016

Who Is Leading the Replication Fork, Pol ε or Pol δ?

Peter M J Burgers, Dmitry Gordenin, Thomas A Kunkel

Abstract readLetterComment
In one paragraph

Article in Molecular cell, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Article
  2. Polymorphism ofInternational journal of molecular sciences · 2023
    Article
  3. Review
  4. Structure and function relationships in mammalian DNA polymerases.Cellular and molecular life sciences : CMLS · 2020
    Review
  5. Plant DNA Polymerases.International journal of molecular sciences · 2019
    Review
  6. Review
  7. Review
  8. Article
  9. GermlineCancer cell international · 2019
    Article
  10. DNA Damage, Mutagenesis and Cancer.International journal of molecular sciences · 2018
    Review
  11. Review
  12. Article
  13. Eukaryotic DNA Replication Fork.Annual review of biochemistry · 2017
    Review
  14. Review
  15. Alterations in cellular metabolism triggered byProceedings of the National Academy of Sciences of the United States of America · 2017
    Article
  16. CMG-Pol epsilon dynamics suggests a mechanism for the establishment of leading-strand synthesis in the eukaryotic replisome.Proceedings of the National Academy of Sciences of the United States of America · 2017
    Article
  17. Review
  18. Quality control mechanisms exclude incorrect polymerases from the eukaryotic replication fork.Proceedings of the National Academy of Sciences of the United States of America · 2017
    Article
  19. Article
  20. Architecture of the Saccharomyces cerevisiae Replisome.Advances in experimental medicine and biology · 2017
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Peter M J BurgersDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Dmitry GordeninGenome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC 27709, USA.
Thomas A KunkelGenome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC 27709, USA. Electronic address: kunkel@niehs.nih.gov.

Funding

Structure-Function Studies Of DNA Replication FidelityZIAES065070 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI KUNKEL, THOMAS A · 2009 to 2025
$30.6M
Genome-wide hypermutation and structural instabilityZIAES103266 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI GORDENIN, DMITRY · 2015 to 2025
$18.0M
ENZYMOLOGY OF REPLICATION OF YEAST CHROMOSOMAL DNAR01GM032431 · NIGMS · WASHINGTON UNIVERSITY · PI BURGERS, PETER M · 1985 to 2015
$6.5M
NIGMS NIH HHS R01 GM032431
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

DNA ReplicationDNA, FungalDNA Polymerase IIISaccharomyces cerevisiae ProteinsDNA, FungalDNA Polymerase IIISaccharomyces cerevisiae Proteins

Identifiers

PMID26895421
PMCPMC4838066

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.