Evidence map›Paper›PMID 26895413›Full record

ReviewCancer nursing

A Review of the Literature on Multiple Co-occurring Symptoms in Patients With Colorectal Cancer Who Received Chemotherapy Alone or Chemotherapy With Targeted Therapies.

Ilufredo Y Tantoy, Janine K Cataldo, Bradley E Aouizerat, Anand Dhruva, Christine Miaskowski

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cancer nursing. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Symptom clusters in colorectal cancer: a systematic review of assessment tools, statistical methods, and symptom patterns.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
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  10. The health-related quality of life of lung cancer patients with EGFR-TKI-related skin adverse drug reactions and its relationship with coping style and self-management.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
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  13. Distinct profiles of multiple co-occurring symptoms in patients with gastrointestinal cancers receiving chemotherapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ilufredo Y TantoyAuthor Affiliations: Department of Physiological Nursing, School of Nursing (Mr Tantoy and Drs Cataldo, Aouizerat, and Miaskowski), School of Medicine (Dr Dhruva), and Institute for Human Genetics (Dr Aouizerat), University of California, San Francisco.
Janine K Cataldo
Bradley E Aouizerat
Anand Dhruva
Christine Miaskowski

Funding

NURSING RESEARCH TRAINING IN SYMPTOM MANAGEMENTT32NR007088 · NINR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LEE, KATHRYN · 1996 to 2015
$7.5M
Symptoms Clusters in Oncology Patients Receiving ChemotherapyR01CA134900 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AOUIZERAT, BRADLEY E, MIASKOWSKI, CHRISTINE A. · 2009 to 2014
$5.9M
Advancing the Science of Symptom Management in Oncology PatientsK05CA168960 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MIASKOWSKI, CHRISTINE A. · 2013 to 2017
$453k
NCI NIH HHS K05 CA168960NCI NIH HHS R01 CA134900NINR NIH HHS T32 NR007088
6 · The paper itself

Abstract

backgroundPatients with colorectal cancer (CRC) rarely experience a single symptom associated with their disease and its treatment.

objectivePurpose of this literature review was to summarize the current state of knowledge of multiple co-occurring symptoms in CRC patients who received chemotherapy (CTX) alone or CTX with targeted therapies.

methodsComprehensive literature search was conducted from 1990 to 2014. These studies were evaluated in terms of the occurrence of multiple co-occurring symptoms in CRC patients who received CTX alone or CTX with targeted therapies; the most common symptom assessment and quality of life (QOL) instruments used; and the associations identified between select demographic and treatment characteristics, QOL, and multiple co-occurring symptoms.

resultsOnly 5 studies met this review's inclusion criteria. Two studies compared symptoms in patients who received CTX alone or CTX with targeted therapies, and only 1 study reported on symptom occurrence. Of the 5 studies identified, only 2 used the same instrument to assess symptoms, and only 2 studies evaluated for associations between demographic and treatment characteristics and symptom burden, as well as QOL outcomes.

conclusionsGiven the larger number of patients with CRC, as well as the increased number of CRC patients who will receive targeted therapies with or without CTX, future studies need to describe the occurrence, severity, and distress of multiple co-occurring symptoms and their impact on CRC patients' QOL. IMPLICATIONS FOR PRACTICE: To deliver effective symptom management interventions, the most common, severe, and distressing symptoms that CRC patients experience need to be identified.

Indexed as

Molecular Targeted TherapyColorectal NeoplasmsDrug TherapyHumansSymptom Assessment

Identifiers

PMID26895413
PMCPMC4990511

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.