Evidence map›Paper›PMID 26895332›Full record

ReviewAdvances in therapy2016

Cervical Lymph Node Metastasis in High-Grade Transformation of Head and Neck Adenoid Cystic Carcinoma: A Collective International Review.

Henrik Hellquist, Alena Skálová, Leon Barnes, Antonio Cardesa, Lester D R Thompson, Asterios Triantafyllou, Michelle D Williams, Kenneth O Devaney, Douglas R Gnepp, Justin A Bishop and 22 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Advances in therapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Post-operative radiotherapy in adenoid cystic carcinoma of salivary glands versus surgery alone: what is the evidence about survival and local control? A systematic review and meta-analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024
    Pooled it
  2. Guideline
  3. Elective neck dissection in adenoid cystic carcinoma of head and neck: yes or no? A systematic review.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2019
    Pooled it
  4. Review
  5. Observational
  6. Article
  7. Review
  8. Article
  9. High-grade transformation of head and neck adenoid cystic carcinoma demonstrates distinctive clinicopathological features and an unfavorable prognosis: a matched case-control study of the largest series in China.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2024
    Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Review
  16. Article
  17. Lacrimal Gland Adenoid Cystic Carcinoma with High Grade Transformation: A Case Report and Current Concepts in Multi Modality Management.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2022
    Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors.

Henrik HellquistDepartment of Biomedical Sciences and Medicine, University of Algarve, Faro, Portugal.
Alena SkálováDepartment of Pathology, Faculty of Medicine in Plzen, Charles University in Prague, Plzen, Czech Republic.
Leon BarnesDepartment of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Antonio CardesaDepartment of Anatomic Pathology, Hospital Clinic, University of Barcelona, Barcelona, Spain.
Lester D R ThompsonSouthern California Permanente Medical Group, Woodland Hills, CA, USA.
Asterios TriantafyllouOral and Maxillofacial Pathology, School of Dentistry, University of Liverpool and Cellular Pathology, Liverpool Clinical Laboratories, Liverpool, UK.
Michelle D WilliamsDepartment of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Kenneth O DevaneyDepartment of Pathology, Allegiance Health, Jackson, MI, USA.
Douglas R GneppUniversity Pathologists, Providence, RI, USA.
Justin A BishopDepartments of Pathology and Otolaryngology-Head and Neck Surgery, The Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Bruce M WenigDepartment of Pathology, Beth Israel Medical Center, New York, NY, USA.
Carlos SuárezFundación de Investigación e Innovación Biosanitaria del Principado de Asturias, Oviedo, Spain.
Juan P RodrigoDepartment of Otolaryngology, Hospital Universitario Central de Asturias, Oviedo, Spain.
Andrés Coca-PelazDepartment of Otolaryngology, Hospital Universitario Central de Asturias, Oviedo, Spain.
Primož StrojanDepartment of Radiation Oncology, Institute of Oncology, Ljubljana, Slovenia.
Jatin P ShahHead and Neck Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Marc HamoirDepartment of Head and Neck Surgery, Head and Neck Oncology Program, St Luc University Hospital and King Albert II Cancer Institute, Brussels, Belgium.
Patrick J BradleyDepartment of Otolaryngology-Head and Neck Surgery, Nottingham University Hospitals, Queens Medical Centre Campus, Nottingham, UK.
Carl E SilverDepartments of Surgery and Otolaryngology-Head and Neck Surgery, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA.
Pieter J SlootwegDepartment of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands.
Vincent Vander PoortenEuropean Salivary Gland Society, Geneva, Switzerland.
Afshin TeymoortashDepartment of Otolaryngology-Head and Neck Surgery, Philipp University, Marburg, Germany.
Jesus E MedinaDepartment of Otorhinolaryngology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
K Thomas RobbinsDivision of Otolaryngology-Head and Neck Surgery, Southern Illinois University School of Medicine, Springfield, IL, USA.
Karen T PitmanDepartment of Surgery, Banner MD Anderson Cancer Center, Gilbert, AZ, USA.
Luiz P KowalskiDepartment of Head and Neck Surgery and Otorhinolaryngology, A. C. Camargo Cancer Center, São Paulo, Brazil.
Remco de BreeDepartment of Head and Neck Surgical Oncology, UMC Utrecht Cancer Center, University Medical Center Utrecht, Utrecht, The Netherlands.
William M MendenhallDepartment of Radiation Oncology, University of Florida, Gainesville, FL, USA.
Jean Anderson EloyDepartment of Otolaryngology-Head and Neck Surgery, Neurological Institute of New Jersey, Rutgers New Jersey Medical School, Newark, NJ, USA.
Robert P TakesDepartment of Otolaryngology-Head and Neck Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.
Alessandra RinaldoUniversity of Udine School of Medicine, Udine, Italy.
Alfio FerlitoCoordinator of the International Head and Neck Scientific Group, Padua, Italy. a.ferlito@uniud.it.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

Adenoid cystic carcinoma (AdCC) is among the most common malignant tumors of the salivary glands. It is characterized by a prolonged clinical course, with frequent local recurrences, late onset of metastases and fatal outcome. High-grade transformation (HGT) is an uncommon phenomenon among salivary carcinomas and is associated with increased tumor aggressiveness. In AdCC with high-grade transformation (AdCC-HGT), the clinical course deviates from the natural history of AdCC. It tends to be accelerated, with a high propensity for lymph node metastasis. In order to shed light on this rare event and, in particular, on treatment implications, we undertook this review: searching for all published cases of AdCC-HGT. We conclude that it is mandatory to perform elective neck dissection in patients with AdCC-HGT, due to the high risk of lymph node metastases associated with transformation.

Indexed as

AdultCarcinoma, Adenoid CysticFemaleHumansLymphatic MetastasisLymph NodesMaleMiddle AgedSalivary Gland NeoplasmsAdenoid cystic carcinomaDedifferentiationFatal outcomeHigh-grade transformationLocal recurrenceLymphatic metastasisNeck dissectionNeoplasm recurrenceSalivary glands

Identifiers

PMID26895332
PMCPMC4833802

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.